Lee Hsun-Hua, Yeh Chun-Ting, Ou Ju-Chi, Ma Hon-Ping, Chen Kai-Yun, Chang Cheng-Fu, Lai Jing-Huei, Liao Kuo-Hsing, Lin Chien-Min, Lin Shu-Yu, Wu Dean, Huang Yao-Hsien, Hu Chaur-Jong, Hong Chien-Tai
Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Department of Emergency Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Acta Neurol Taiwan. 2017 Mar 15;26(1):13-19.
Mild traumatic brain injury (mTBI) is a major public health concern. The apolipoprotein E (APOE) gene contains three polymorphisms, and the APOE4 polymorphism may affect several physiological states, such as the recovery from mTBI as well as sleep. This study aims to investigate the association between APOE4 with the recovery of sleep disturbance after mTBI.
From May 2012 to Aug 2015, 189 mTBI patients completed baseline (1st week post-mTBI) and follow-up (6th week post-mTBI) sleep assessments that involved using the Pittsburgh Sleep Quality Index (PSQI). APOE genotypes were determined by sequencing the products of polymerase chain reaction from genomic DNA. Statistical analyses were performed using the Wilcox signed-rank or chi-square test.
Thirty-five (18.5%) participants were APOE4 carriers. At baseline, the demographic data and the severity of sleep disturbance were similar in both groups. APOE4 carriers demonstrated significant improvement in the overall PSQI score (8.34±3.9 at baseline and 7.43±3.99 at follow-up, p = 0.05) and scores of several PSQI subscales, including sleep disturbance, sleep latency, daytime dysfunction caused by sleepiness, and overall sleep quality, which was similar to APOE4 noncarriers.
APOE4 is not associated with the recovery of sleep disturbance after mTBI.
轻度创伤性脑损伤（mTBI）是一个重大的公共卫生问题。载脂蛋白E（APOE）基因包含三种多态性，APOE4多态性可能会影响多种生理状态，如mTBI后的恢复以及睡眠。本研究旨在探讨APOE4与mTBI后睡眠障碍恢复之间的关联。
2012年5月至2015年8月，189例mTBI患者完成了基线（mTBI后第1周）和随访（mTBI后第6周）睡眠评估，评估采用匹兹堡睡眠质量指数（PSQI）。通过对基因组DNA聚合酶链反应产物进行测序来确定APOE基因型。使用Wilcox符号秩和检验或卡方检验进行统计分析。
35名（18.5%）参与者为APOE4携带者。在基线时，两组的人口统计学数据和睡眠障碍严重程度相似。APOE4携带者在总体PSQI评分（基线时为8.34±3.9，随访时为7.43±3.99，p = 0.05）以及几个PSQI子量表评分方面有显著改善，这些子量表包括睡眠障碍、入睡潜伏期、由困倦引起的日间功能障碍和总体睡眠质量，这与非APOE4携带者相似。
APOE4与mTBI后睡眠障碍的恢复无关。
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