Su Hang, Liu Ruijie, Chang Ming, Huang Jianhua, Wang Xingguo
State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, P. R. China.
Food Funct. 2017 Sep 20;8(9):3091-3103. doi: 10.1039/c7fo00433h.
The aim of the present study was to investigate the effect of increasing dietary linoleic acid (LA) intake on the blood concentrations of inflammatory markers including cytokines, acute phase reactants and adhesion molecules in adults.
We comprehensively searched PubMed, Embase and Cochrane Library for eligible studies. Overall, 30 randomized controlled studies involving 1377 subjects were included for meta-analysis.
No significant effect of higher LA intake was observed for cytokines: tumor necrosis factor (SMD: -0.01; 95% CI: -0.19 to 0.17), interleukin-6 (SMD: 0.11, 95% CI: -0.07 to 0.29), adiponectin (SMD: 0.17, 95% CI: -0.17 to 0.50) and monocyte chemoattractant protein 1 (SMD: 0.14, 95% CI: -0.33 to 0.60). Pooled effect size from 16 studies showed that the C-reactive protein (CRP) concentration was not significantly affected by increasing LA intake (SMD = 0.09, 95% CI: -0.05 to 0.24). However, subgroup and meta-regression analysis suggested that in subjects with a more profound increase of dietary LA intake, LA might increase the blood CRP level. Other acute phase reactants including fibrinogen and plasminogen activator inhibitor-1 and adhesion molecules were not significantly changed when LA was increased in diet. No significant heterogeneity or publication bias was observed, although only a limited number of eligible studies were included for some markers.
Our meta-analysis suggested that increasing dietary LA intake does not have a significant effect on the blood concentrations of inflammatory markers. However, the extent of change in dietary LA intake might affect the effect of LA supplementation on CRP.
本研究旨在探讨增加成年人饮食中亚油酸（LA）摄入量对包括细胞因子、急性期反应物和黏附分子在内的炎症标志物血液浓度的影响。
我们全面检索了PubMed、Embase和Cochrane图书馆中的相关研究。总体而言，纳入了30项涉及1377名受试者的随机对照研究进行荟萃分析。
对于细胞因子，未观察到较高LA摄入量有显著影响：肿瘤坏死因子（标准化均值差：-0.01；95%置信区间：-0.19至0.17）、白细胞介素-6（标准化均值差：0.11，95%置信区间：-0.07至0.29）、脂联素（标准化均值差：0.17，95%置信区间：-0.17至0.50）和单核细胞趋化蛋白1（标准化均值差：0.14，95%置信区间：-0.33至0.60）。16项研究的合并效应量表明，增加LA摄入量对C反应蛋白（CRP）浓度无显著影响（标准化均值差 = 0.09，95%置信区间：-0.05至0.24）。然而，亚组和元回归分析表明，在饮食中LA摄入量增加幅度更大的受试者中，LA可能会增加血液中CRP水平。当饮食中LA增加时，包括纤维蛋白原和纤溶酶原激活物抑制剂-1在内的其他急性期反应物以及黏附分子均无显著变化。尽管某些标志物纳入的合格研究数量有限，但未观察到显著的异质性或发表偏倚。
我们的荟萃分析表明，增加饮食中LA摄入量对炎症标志物的血液浓度没有显著影响。然而，饮食中LA摄入量的变化程度可能会影响LA补充对CRP的作用。
