Department of Chemistry, University of Houston , Houston, Texas 77204, United States.
Org Lett. 2017 Aug 18;19(16):4247-4250. doi: 10.1021/acs.orglett.7b01901. Epub 2017 Jul 28.
A general method for synthesis of 1,2-bis-trifluoromethylthioarenes has been developed. Arynes generated from silyl aryl triflates or halides react with bis(trifluoromethyl)disulfide to afford 1,2-bis-trifluoromethylthioarenes. Aryl, alkyl, ester, halide, and methoxy functionalities are compatible with reaction conditions. Use of bis(perfluoroaryl)disulfides gave moderate yields of aryne disulfenylation or cyclization to fluorinated dibenzothiophenes.
一种通用的合成 1,2-双(三氟甲基硫代)芳烃的方法已经被开发出来。芳基三氟甲磺酸酯或卤化物生成的芳基炔与双(三氟甲基)二硫化物反应,得到 1,2-双(三氟甲基硫代)芳烃。芳基、烷基、酯基、卤化物和甲氧基官能团与反应条件兼容。使用双(全氟芳基)二硫化物可以中等产率得到芳基炔二硫代反应或环化生成氟化二苯并噻吩。