Truong Thanh, Daugulis Olafs
Department of Chemistry, University of Houston, Houston, TX 77204-5003, USA.
Chem Sci. 2013;4:531-535. doi: 10.1039/c2sc21288a.
Two reactions of phenols with arynes have been developed. If LiTMP base is employed, arynes generated from aryl chlorides react with phenols to form helicenes. -Arylation of phenols can be achieved by employing BuONa base in the presence of AgOAc. Direct arylation of binol was achieved leading to the shortest pathway to o,o'-diarylbinols.
已经开发出酚类与芳炔的两种反应。如果使用LiTMP碱,由芳基氯生成的芳炔与酚类反应形成螺旋烯。在醋酸银存在下使用丁醇钠碱可实现酚类的芳基化。实现了联萘酚的直接芳基化,从而得到了制备邻,邻'-二芳基联萘酚的最短途径。