Cho Seung-Yeon, Lee Young-Eun, Doo Kyeong-Hee, Lee Ji-Hyun, Jung Woo-Sang, Moon Sang-Kwan, Park Jung-Mi, Ko Chang-Nam, Kim Ho, Rhee Hak Young, Park Hi-Joon, Park Seong-Uk
1 Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University , Seoul, Republic of Korea.
2 Stroke and Neurological Disorders Center, Kyung Hee University Hospital at Gangdong , Seoul, Republic of Korea.
J Altern Complement Med. 2018 Jan;24(1):25-32. doi: 10.1089/acm.2016.0250. Epub 2017 Jul 28.
The aim of this study was to evaluate the efficacy of acupuncture and bee venom acupuncture (BVA) for idiopathic Parkinson's disease (IPD) through a sham-controlled trial. We also investigated whether there is a sustained therapeutic effect by completing follow-up assessments after treatment completion.
A single center, double-blind, three-armed randomized controlled trial.
SETTINGS/LOCATION: This study was performed at a university hospital in Seoul, Republic of Korea.
Seventy-three (73) patients with IPD were the subjects. They were randomly assigned to the active treatment group, sham treatment group, or conventional treatment group.
The active treatment group received acupuncture and BVA and the sham group received sham acupuncture and normal saline injections, twice a week for 12 weeks. The conventional treatment group maintained anti-parkinsonian drugs without additional intervention.
The Unified Parkinson's Disease Rating Scale (UPDRS) part II and part III score, postural instability and gait disturbance (PIGD) score, gait speed and number, Parkinson's Disease Quality of Life Questionnaire, Beck Depression Inventory, and postural stability at baseline and at 12, 16, and 20 weeks.
Sixty-three (63) patients provided a complete data of assessments, including a final follow-up. After 12 weeks of treatment, a significant difference was observed between the active treatment group and the conventional treatment group. After the end of the treatment, the treatment effects were maintained significantly in the active treatment group only.
It is suggested that the combined treatment of acupuncture and BVA might be safe and useful adjunctive treatment for patients with IPD.
本研究旨在通过一项假对照试验评估针刺和蜂毒针刺（BVA）治疗特发性帕金森病（IPD）的疗效。我们还通过在治疗结束后完成随访评估来调查是否存在持续治疗效果。
单中心、双盲、三臂随机对照试验。
设置/地点：本研究在韩国首尔的一家大学医院进行。
73例IPD患者作为受试者。他们被随机分配到积极治疗组、假治疗组或传统治疗组。
积极治疗组接受针刺和BVA，假治疗组接受假针刺和生理盐水注射，每周两次，共12周。传统治疗组维持抗帕金森病药物治疗，无额外干预。
统一帕金森病评定量表（UPDRS）第二部分和第三部分评分、姿势不稳和步态障碍（PIGD）评分、步态速度和步数、帕金森病生活质量问卷、贝克抑郁量表以及基线时、第12、16和20周时的姿势稳定性。
63例患者提供了完整的评估数据，包括最后一次随访。治疗12周后，积极治疗组与传统治疗组之间观察到显著差异。治疗结束后，仅积极治疗组的治疗效果得到显著维持。
提示针刺和BVA联合治疗可能是IPD患者安全有效的辅助治疗方法。
