Veraldi Stefano, Schianchi Rossana, Pontini Paolo, Gorani Alberto
a Department of Pathophysiology and Transplantation , Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico , Milan , Italy.
b Centro Dermatologico Milanese (C.D.M.) , Milan , Italy.
J Dermatolog Treat. 2018 Mar;29(2):200-201. doi: 10.1080/09546634.2017.1360988. Epub 2017 Sep 19.
Tinea corporis is a common mycotic infection in children. Staphylococcus aureus superinfections may be observed in atopic children with tinea corporis suffering from severe pruritus and consequent scratching.
From 2006 to 2011, we observed 288 children with mycologically proven tinea corporis. In 39 of them (13.5%) tinea corporis was superinfected by S. aureus: all these children were affected by atopic dermatitis. We interpreted these bacterial superinfections as the clinical result of scratching due to pruritus.
In 2012, we decided to treat all children with a single lesion of tinea corporis with a combination of 1% isoconazole nitrate and 0.1% diflucortolone valerate cream (one application/day for 5-7 days), followed by a treatment with isoconazole or clotrimazole or ciclopirox cream (two applications/day for two weeks).
From 2012 to 2014, we observed 108 children with tinea corporis confirmed by mycological examinations. Clinical and mycological recovery was observed in 93 of them (86.1%). Only four of these children (3.7%) developed S. aureus superinfections.
Our study in atopic children with tinea corporis superinfected by S. aureus confirms that a topical therapy with the association isoconazole-diflucortolone is useful and safe.
体癣是儿童常见的真菌感染。在患有严重瘙痒并因此搔抓的特应性体癣患儿中，可能会观察到金黄色葡萄球菌的二重感染。
2006年至2011年，我们观察了288例经真菌学证实的体癣患儿。其中39例（13.5%）体癣被金黄色葡萄球菌二重感染：所有这些患儿均患有特应性皮炎。我们将这些细菌二重感染解释为瘙痒引起搔抓的临床结果。
2012年，我们决定对所有单发体癣患儿采用1%硝酸益康唑和0.1%戊酸倍他米松乳膏联合治疗（每天涂抹1次，持续5 - 7天），随后用益康唑或克霉唑或环吡酮乳膏治疗（每天涂抹2次，持续两周）。
2012年至2014年，我们观察了108例经真菌学检查确诊的体癣患儿。其中93例（86.1%）实现了临床和真菌学治愈。这些患儿中只有4例（3.7%）发生了金黄色葡萄球菌二重感染。
我们对金黄色葡萄球菌二重感染的特应性体癣患儿的研究证实，益康唑 - 倍他米松联合局部治疗是有效且安全的。
