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60岁以上患者中根据年龄、性别、血压及既往心血管疾病情况进行降压药物治疗的疗效

Efficacy of antihypertensive drug treatment according to age, sex, blood pressure, and previous cardiovascular disease in patients over the age of 60.

作者信息

Amery A, Birkenhäger W, Brixko R, Bulpitt C, Clement D, Deruyttere M, De Schaepdryver A, Dollery C, Fagard R, Forette F

出版信息

Lancet. 1986 Sep 13;2(8507):589-92. doi: 10.1016/s0140-6736(86)92424-4.

DOI:10.1016/s0140-6736(86)92424-4
PMID:2875317
Abstract

Results of the European Working Party on High Blood Pressure in the Elderly (EWPHE) trial have been analysed in relation to age, sex, blood pressure, and previous cardiovascular disease. Cardiovascular mortality and the cardiovascular study-terminating events were significantly and independently related to treatment, age, cardiovascular complications at randomisation, and systolic but not diastolic blood pressure. The benefits of treatment observed in the trial seemed to be independent of entry blood pressure and the presence or absence of cardiovascular complications at entry. There was some evidence that treatment effect decreases with advancing age. Little or no benefit from treatment could be demonstrated in patients over the age of 80 years, the great majority of whom were women.

摘要

欧洲老年高血压工作组(EWPHE)试验的结果已根据年龄、性别、血压和既往心血管疾病进行了分析。心血管死亡率和导致心血管研究终止的事件与治疗、年龄、随机分组时的心血管并发症以及收缩压而非舒张压显著且独立相关。试验中观察到的治疗益处似乎与入组时的血压以及入组时是否存在心血管并发症无关。有一些证据表明治疗效果会随着年龄的增长而降低。在80岁以上的患者中几乎没有显示出治疗益处,其中绝大多数是女性。

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1
Efficacy of antihypertensive drug treatment according to age, sex, blood pressure, and previous cardiovascular disease in patients over the age of 60.60岁以上患者中根据年龄、性别、血压及既往心血管疾病情况进行降压药物治疗的疗效
Lancet. 1986 Sep 13;2(8507):589-92. doi: 10.1016/s0140-6736(86)92424-4.
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Isolated systolic hypertension: data from the European Working Party on High Blood Pressure in the Elderly.单纯收缩期高血压:来自欧洲老年高血压工作组的数据。
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Influence of antihypertensive drug treatment on morbidity and mortality in patients over the age of 60 years. European Working Party on High blood pressure in the Elderly (EWPHE) results: sub-group analysis on entry stratification.降压药物治疗对60岁以上患者发病率和死亡率的影响。欧洲老年高血压工作组(EWPHE)研究结果:入组分层的亚组分析。
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The progress of patients in the European Working Party on Hypertension in the Elderly trial.
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Antihypertensive therapy in patients above age 60. Third interim report of the European Working Party on High blood pressure in Elderly (EWPHE).60岁以上患者的抗高血压治疗。欧洲老年高血压工作组(EWPHE)第三次中期报告。
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Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial.欧洲老年高血压工作组试验的死亡率和发病率结果。
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Relation between mortality and treated blood pressure in elderly patients with hypertension: report of the European Working Party on High Blood Pressure in the Elderly.老年高血压患者死亡率与血压治疗的关系:欧洲老年高血压工作组报告
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Antihypertensive therapy in patients above age 60 with systolic hypertension. A progress report of the European Working Party on High Blood Pressure in the Elderly (EWPHE).60岁以上收缩期高血压患者的抗高血压治疗。欧洲老年高血压工作组(EWPHE)的进展报告。
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European working party on high blood pressure in elderly (EWPHE): organization of a double-blind multicentre trial on antihypertensive therapy in elderly patients.欧洲老年高血压工作组(EWPHE):老年患者抗高血压治疗双盲多中心试验的组织情况
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Comparison of two combined diuretics in the treatment of essential hypertension.两种联合利尿剂治疗原发性高血压的比较。
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