Amery A, Birkenhäger W, Brixko R, Bulpitt C, Clement D, Deruyttere M, De Schaepdryver A, Dollery C, Fagard R, Forette F
Lancet. 1986 Sep 13;2(8507):589-92. doi: 10.1016/s0140-6736(86)92424-4.
Results of the European Working Party on High Blood Pressure in the Elderly (EWPHE) trial have been analysed in relation to age, sex, blood pressure, and previous cardiovascular disease. Cardiovascular mortality and the cardiovascular study-terminating events were significantly and independently related to treatment, age, cardiovascular complications at randomisation, and systolic but not diastolic blood pressure. The benefits of treatment observed in the trial seemed to be independent of entry blood pressure and the presence or absence of cardiovascular complications at entry. There was some evidence that treatment effect decreases with advancing age. Little or no benefit from treatment could be demonstrated in patients over the age of 80 years, the great majority of whom were women.
欧洲老年高血压工作组(EWPHE)试验的结果已根据年龄、性别、血压和既往心血管疾病进行了分析。心血管死亡率和导致心血管研究终止的事件与治疗、年龄、随机分组时的心血管并发症以及收缩压而非舒张压显著且独立相关。试验中观察到的治疗益处似乎与入组时的血压以及入组时是否存在心血管并发症无关。有一些证据表明治疗效果会随着年龄的增长而降低。在80岁以上的患者中几乎没有显示出治疗益处,其中绝大多数是女性。