An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles.
作者信息
Kueh Andrew J, Pal Martin, Tai Lin, Liao Yang, Smyth Gordon K, Shi Wei, Herold Marco J
机构信息
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Victoria 3052, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3050, Australia.
出版信息
Cell Death Differ. 2017 Oct;24(10):1821-1822. doi: 10.1038/cdd.2017.122. Epub 2017 Jul 28.
Abstract
摘要
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An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles.关于在单细胞期小鼠胚胎中使用CRISPR/Cas9技术生成复杂突变等位基因的最新进展。
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Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.缺乏促生存BCL-2家族成员A1所有功能异构体的小鼠的特征表明造血系统存在轻微缺陷。
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