Shigemori M, Tokutomi T, Kawaba T, Nakashima H, Kuramoto S
Neurol Res. 1986 Jun;8(2):105-8. doi: 10.1080/01616412.1986.11739740.
The changes in the two consistent components of epidural pressure pulse wave (EDP-PW), P1 and P2 waves, and mean velocity of common carotid blood flow (CBFV) were studied in 21 patients with acute intracranial hypertension to investigate the origin of th the amplitude change in these components. The amplitudes of P2 wave increased progressively with the rise of EDP, but those of P1 wave remained nearly invariable at EDP of more than 20-30 mmHg which is incompatible with the changes in CBFV. Jugular vein compression caused in rapid rise of EDP and a proportionate increase in the magnitudes of both waves. Hyperventilation and mannitol administration caused a disproportionate reduction in the amplitudes of P2 wave with a fall of EDP. But mannitol at high EDP (more than 40 mmHg) caused a mild fall of EDP and some increase in the amplitudes of P2 wave. These results indicate that the variations in the amplitudes of P1 wave reflect the changes in vascular resistance of the large intracranial conductive arteries, while those of P2 wave result from the changes in the volume of the cerebral bulk. The increase in the amplitudes of P2 wave induced by mannitol at high EDP may suggest a defective autoregulation of the cerebral vessels.
对21例急性颅内高压患者的硬膜外压力脉搏波（EDP-PW）的两个一致成分P1波和P2波及颈总动脉血流平均速度（CBFV）的变化进行了研究，以探讨这些成分幅度变化的起源。P2波的幅度随EDP升高而逐渐增加，但在EDP超过20-30 mmHg时，P1波的幅度几乎保持不变，这与CBFV的变化不一致。压迫颈静脉导致EDP迅速升高，且两波幅度成比例增加。过度通气和使用甘露醇导致EDP下降时P2波幅度不成比例地降低。但在高EDP（超过40 mmHg）时使用甘露醇导致EDP轻度下降，P2波幅度有所增加。这些结果表明，P1波幅度的变化反映了颅内大传导动脉血管阻力的变化，而P2波幅度的变化则源于脑容量的变化。高EDP时甘露醇诱导的P2波幅度增加可能提示脑血管自动调节功能缺陷。
