Melo Xavier, Santos Diana A, Ornelas Rui, Fernhall Bo, Santa-Clara Helena, Sardinha Luís B
a Faculdade de Motricidade Humana, CIPER-Centro Interdisciplinar de Estudo da Performance Humana , Universidade de Lisboa , Lisboa , Portugal.
b Ginásio Clube Português , Lisboa , Portugal.
Blood Press. 2018 Feb;27(1):19-24. doi: 10.1080/08037051.2017.1360724. Epub 2017 Jul 28.
We examined whether exposure to high PP in adolescence predicts carotid artery intima-media thickness (IMT) and stiffness indices at young adulthood.
Seventy-nine participants had their brachial systolic (SBP) and diastolic blood (DBP) pressures taken at the age of 15-16 years and later at young adulthood (29-31 years). Carotid IMT, distensibility and stiffness index β were measured at young adulthood. Linear and logistical regression analysis were performed.
PP at adolescence and at young adulthood predicted vascular health independently of sex, body mass index, and mean arterial pressure, explaining up to 37% of the variance. When analyzing its single constituents, at adolescence DBP was more predictive of vascular health, whereas DBP and SBP were equally important at young adulthood. Adolescents with high PP were at risk for increased carotid IMT (OR: 4.04-4.09), even if PP decreased at young adulthood. Young adults with high PP were at risk for increased stiffness regardless of adolescence PP (OR: 4.64-7.35).
PP at adolescence and young adulthood may be a better predictor of early pathological changes in carotid artery structure and stiffness. Whereas carotid IMT in young adults appears to be influenced by PP at adolescence, carotid stiffness depends primarily on current PP.
我们研究了青少年时期暴露于高脉压是否能预测成年早期的颈动脉内膜中层厚度（IMT）和僵硬度指数。
79名参与者在15 - 16岁时测量了肱动脉收缩压（SBP）和舒张压（DBP），并在成年早期（29 - 31岁）再次测量。在成年早期测量颈动脉IMT、扩张性和僵硬度指数β。进行线性和逻辑回归分析。
青少年时期和成年早期的脉压独立于性别、体重指数和平均动脉压预测血管健康，解释了高达37%的变异。在分析其单个成分时，青少年时期舒张压对血管健康的预测性更强，而在成年早期舒张压和收缩压同样重要。脉压高的青少年颈动脉IMT增加的风险较高（比值比：4.04 - 4.09），即使成年早期脉压下降。脉压高的年轻成年人无论青少年时期脉压如何，僵硬度增加的风险都较高（比值比：4.64 - 7.35）。
青少年时期和成年早期的脉压可能是颈动脉结构和僵硬度早期病理变化的更好预测指标。成年早期的颈动脉IMT似乎受青少年时期脉压的影响，而颈动脉僵硬度主要取决于当前脉压。
