外周血压和主动脉血压个体间差异相关动脉参数变化的比较分析：2至84岁健康受试者的横断面研究
Comparative Analysis of Arterial Parameters Variations Associated with Inter-Individual Variations in Peripheral and Aortic Blood Pressure: Cross-Sectional Study in Healthy Subjects Aged 2-84 years.
作者信息
Zócalo Yanina, Curcio Santiago, García-Espinosa Victoria, Chiesa Pedro, Giachetto Gustavo, Bia Daniel
机构信息
Physiology Department, School of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
Servicio de Cardiología Pediátrica, Centro Hospitalario Pereira Rossell, ASSE-Ministry of Public Health, Boulevard Artigas 1550, 11600, Montevideo, Uruguay.
出版信息
High Blood Press Cardiovasc Prev. 2017 Dec;24(4):437-451. doi: 10.1007/s40292-017-0231-2. Epub 2017 Sep 25.
INTRODUCTION
The association between arterial parameters and blood pressure (BP) interindividual variations could depend on the arterial segment, BP component (systolic, SBP; diastolic, DBP; pulse pressure, PP) and/or on whether central (cBP) or peripheral (pBP) BP variations are considered.
AIM
To assess and compare arterial parameters variations associated with interindividual variations in cBP and pBP.
METHODS
Healthy subjects (n = 923; 488 males, 2-84 years) were included. pBP and cBP waves were obtained (Mobil-O-Graph; SphygmoCor). Arterial diameter, intima-media thickness, local elastic modulus (carotid, CEM; brachial, BEM; femoral, FEM) and regional (carotid-radial and carotid-femoral pulse wave velocity; crPWV and cfPWV) arterial stiffness were determined. Associations between BP and arterial parameters interindividual variations were analyzed and compared (correlations; linear regressions; slopes comparisons) considering data transformed into z-scores.
RESULTS
Given a variation in z-cSBP or z-pSBP, z-CEM, z-FEM and z-cfPWV (stiffness indexes), were among the parameters with major BP-associated variations. z-crPWV and z-cfPWV, rather than local stiffness indexes were the parameters with major variations associated with z-DBP variations. z-cPP or z-pPP were associated with z-CEM and z-FEM variations, but not with brachial or regional stiffness variations. Most of the arterial parameters-BP slopes did not show significant differences when considering a variation in z-cSBP and z-pSBP. z-CEM and z-FEM were mainly associated with z-cPP and z-pPP variations, respectively.
CONCLUSION
Disregard of age and sex, the variations in arterial parameters associated with BP interindividual variations showed differences depending on whether variations were central or peripheral; in SBP, DBP or PP and depending on the arterial segment considered.
引言
动脉参数与血压（BP）个体间差异之间的关联可能取决于动脉节段、血压成分（收缩压，SBP；舒张压，DBP；脉压，PP），和/或取决于所考虑的是中心血压（cBP）还是外周血压（pBP）的变化。
目的
评估和比较与cBP和pBP个体间差异相关的动脉参数变化。
方法
纳入健康受试者（n = 923；488名男性，年龄2至84岁）。获取pBP和cBP波形（Mobil-O-Graph；SphygmoCor）。测定动脉直径、内膜中层厚度、局部弹性模量（颈动脉，CEM；肱动脉，BEM；股动脉，FEM）以及区域（颈动脉-桡动脉和颈动脉-股动脉脉搏波速度；crPWV和cfPWV）动脉僵硬度。考虑将数据转换为z分数，分析并比较BP与动脉参数个体间差异之间的关联（相关性；线性回归；斜率比较）。
结果
给定z-cSBP或z-pSBP的变化，z-CEM、z-FEM和z-cfPWV（僵硬度指标）是与BP相关变化较大的参数。z-crPWV和z-cfPWV而非局部僵硬度指标是与z-DBP变化相关较大的参数。z-cPP或z-pPP与z-CEM和z-FEM变化相关，但与肱动脉或区域僵硬度变化无关。在考虑z-cSBP和z-pSBP的变化时，大多数动脉参数-BP斜率未显示出显著差异。z-CEM和z-FEM分别主要与z-cPP和z-pPP变化相关。
结论
不考虑年龄和性别，与BP个体间差异相关的动脉参数变化根据变化是中心性还是外周性、是SBP、DBP还是PP以及所考虑的动脉节段而表现出差异。
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