Fredman P, von Holst H, Collins V P, Ammar A, Dellheden B, Wahren B, Granholm L, Svennerholm L
Neurol Res. 1986 Jun;8(2):123-6. doi: 10.1080/01616412.1986.11739744.
Gangliosides in human gliomas were investigated and found to have an altered composition and concentration as compared to normal grey and white matter of brain. The major gangliosides GM1, GD1a, and GT1b were markedly reduced in the tumour tissue and in contrast there was an increase of gangliosides GM3 and GD3, which often appeared as the dominating ones. Moreover, the tumours contained gangliosides, both mono- and oligosialylated, which could not be detected in the normal brain. The concentration of gangliosides, 0.7 +/- 0.4 mumol sialic acid/g, was significantly lower as compared to normal brain grey (p less than 0.001) and white matter (p less than 0.01), which contained 3.5 +/- 0.3 and 1.2 +/- 0.3 mumol sialic acid/g respectively. The tumour tissue concentration of phospholipids was 14 +/- 8 and of cholesterol 19 +/- 12 mumol/g. The appearance in glioma tissue of gangliosides that are not found in normal brain tissue suggests that these are tumour associated and might serve as surface antigens detectable by specific monoclonal antibodies.
对人类神经胶质瘤中的神经节苷脂进行了研究，发现与正常脑灰质和白质相比，其组成和浓度发生了改变。肿瘤组织中主要的神经节苷脂GM1、GD1a和GT1b明显减少，相反，神经节苷脂GM3和GD3有所增加，它们常常成为主要成分。此外，肿瘤中含有单唾液酸和寡唾液酸神经节苷脂，而在正常脑中无法检测到。神经节苷脂的浓度为0.7±0.4μmol唾液酸/克，与分别含有3.5±0.3和1.2±0.3μmol唾液酸/克的正常脑灰质（p＜0.001）和白质（p＜0.01）相比，显著降低。肿瘤组织中磷脂的浓度为14±8，胆固醇的浓度为19±12μmol/克。在神经胶质瘤组织中出现正常脑组织中未发现的神经节苷脂，表明这些是与肿瘤相关的，可能作为可被特异性单克隆抗体检测到的表面抗原。
