Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, UIT-The Arctic University of Tromsø, N-9037 Tromsø, Norway.
Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, UIT-The Arctic University of Tromsø, N-9037 Tromsø, Norway.
Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt B):1908-1913. doi: 10.1016/j.bbadis.2017.07.025. Epub 2017 Jul 25.
Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte mediating both adaptive and maladaptive changes in the heart. NOXs have been suggested as a therapeutic target for several diabetic complications, but their role in diabetic cardiomyopathy is far from elucidated. In this review we aim to provide an overview of the current knowledge regarding the understanding of how NOXs influences cardiac adaptive and maladaptive processes in a "diabetic milieu". This article is part of a Special issue entitled Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers.
在糖尿病期间，全身性变化，如高血糖、血脂异常、激素变化和低度炎症，被认为会导致与糖尿病心肌病发展相关的心肌细胞的结构和功能变化。糖尿病心脏的一个特征是氧化应激增加。NADPH 氧化酶（NOXs）是心肌细胞中产生 ROS 的重要酶，介导心脏的适应性和失调性变化。NOX 已被提议作为几种糖尿病并发症的治疗靶点，但它们在糖尿病心肌病中的作用仍远未阐明。在这篇综述中，我们旨在提供对目前关于 NOX 如何影响“糖尿病环境”中心脏适应性和失调性过程的理解的概述。本文是由 Jan F.C. Glatz、Jason R.B. Dyck 和 Christine Des Rosiers 教授编辑的特刊“肥胖、糖尿病和胰岛素抵抗的心脏适应性”的一部分。
