百岁老人维持 miRNA 生物发生途径，而 80 岁以上老人的该途径受损。
Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians.
机构信息
Facultad de Medicina, Universidad de Valencia, Valencia, Spain; INCLIVA and Spanish Centenarian Study Group, Center for Biomedical Network Research on Frailty and Healthy Aging (CIBERFES), CIBER-ISCIII, Spain.
Facultad de Medicina, Universidad de Valencia, Valencia, Spain; INCLIVA and Spanish Centenarian Study Group, Center for Biomedical Network Research on Frailty and Healthy Aging (CIBERFES), CIBER-ISCIII, Spain.
出版信息
Mech Ageing Dev. 2017 Dec;168:54-57. doi: 10.1016/j.mad.2017.07.003. Epub 2017 Jul 25.
Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Furthermore, factors involved in the control of these miRNAs biogenesis genes are also up-regulated in centenarians. Therefore, the up-regulation of miRNA expression in centenarians can be explained in part because miRNA biogenesis pathway is depressed in octogenarians (ordinary aging) while it is maintained in centenarians (extraordinary aging).
我们之前曾报道，百岁老人而非 80 岁老人上调 miRNA 的表达。我们研究了 miRNA 的生物发生。我们发现，与 80 岁老人相比，百岁老人的 RNA POL II、DROSHA、EXPORTIN 5 和 DICER 上调。此外，参与这些 miRNA 生物发生基因调控的因子在百岁老人中也上调。因此，百岁老人中 miRNA 表达的上调部分可以解释为 miRNA 生物发生途径在 80 岁老人（普通衰老）中受到抑制，而在百岁老人（非凡衰老）中得到维持。
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