Cantú Andrea V, Laird Diana J
Department of Ob/Gyn and Reproductive Sciences, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine & Stem Cell Research, UCSF, 35 Medical Center Way, San Francisco, CA 94043, United States.
Department of Ob/Gyn and Reproductive Sciences, Center for Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine & Stem Cell Research, UCSF, 35 Medical Center Way, San Francisco, CA 94043, United States.
Stem Cell Res. 2017 Oct;24:181-187. doi: 10.1016/j.scr.2017.07.017. Epub 2017 Jul 18.
Comparative studies of primordial germ cell (PGC) development across organisms in many phyla reveal surprising diversity in the route of migration, timing and underlying molecular mechanisms, suggesting that the process of migration itself is conserved. However, beyond the perfunctory transport of cellular precursors to their later arising home of the gonads, does PGC migration serve a function? Here we propose that the process of migration plays an additional role in quality control, by eliminating PGCs incapable of completing migration as well as through mechanisms that favor PGCs capable of responding appropriately to migration cues. Focusing on PGCs in mice, we explore evidence for a selective capacity of migration, considering the tandem regulation of proliferation and migration, cell-intrinsic and extrinsic control, the potential for tumors derived from failed PGC migrants, the potential mechanisms by which migratory PGCs vary in their cellular behaviors, and corresponding effects on development. We discuss the implications of a selective role of PGC migration for in vitro gametogenesis.
对多个门的生物中原始生殖细胞（PGC）发育的比较研究表明，在迁移途径、时间和潜在分子机制方面存在惊人的多样性，这表明迁移过程本身是保守的。然而，除了将细胞前体简单地运输到后来形成的性腺所在地之外，PGC迁移是否具有功能呢？在这里，我们提出迁移过程在质量控制中发挥了额外作用，通过消除无法完成迁移的PGC以及通过有利于能够对迁移线索做出适当反应的PGC的机制。以小鼠的PGC为重点，我们探讨了迁移的选择能力的证据，考虑了增殖和迁移的串联调节、细胞内在和外在控制、源自失败的PGC迁移者的肿瘤的可能性、迁移的PGC在细胞行为上变化的潜在机制以及对发育的相应影响。我们讨论了PGC迁移的选择作用对体外配子发生的影响。
