Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, 91054, Erlangen, Germany.
Sci Rep. 2017 Jul 28;7(1):6821. doi: 10.1038/s41598-017-07273-x.
Neuropeptide Y (NPY) and its receptors (especially Y1, Y2, and Y5) are highly expressed in brain regions involved in learning and memory processes. Accordingly, NPY was shown to modulate cognitive functions in rodents. Here, we investigated possible memory-enhancing effects of NPY and determined the role of the NPY system in the acquisition, consolidation, and retrieval of non-social and social memory in mice, using the object and social discrimination tests, respectively. Intracerebroventricular (icv) infusion of NPY (1 nmol/2 µl) prolonged retention of non-social (object) memory, but not of social memory. This effect was blocked by the Y1 receptor antagonist BIBO3304 trifluoroacetate (2 nmol/2 µl), but not by the Y2 receptor antagonist BIIE0246 (2 nmol/2 µl). While icv infusion of NPY did not affect the acquisition, consolidation, and retrieval of non-social and social memory, icv infusion of BIBO3304 trifluoroacetate and BIIE0246 blocked the consolidation of non-social memory and the retrieval of both non-social and social memory. This study suggests that NPY has memory-enhancing effects in a non-social context by specifically acting on Y1 receptors. It further suggests that the central NPY system exerts differential effects on the sequential phases of non-social and social memory.
神经肽 Y（NPY）及其受体（特别是 Y1、Y2 和 Y5）在参与学习和记忆过程的大脑区域中高度表达。因此，NPY 被证明可以调节啮齿动物的认知功能。在这里，我们研究了 NPY 可能增强记忆的作用，并使用物体和社交辨别测试分别确定了 NPY 系统在非社交和社交记忆的获得、巩固和检索中的作用。脑室内（icv）输注 NPY（1 nmol/2 µl）延长了非社交（物体）记忆的保留时间，但不延长社交记忆的保留时间。这种作用被 Y1 受体拮抗剂 BIBO3304 三氟乙酸盐（2 nmol/2 µl）阻断，但不被 Y2 受体拮抗剂 BIIE0246（2 nmol/2 µl）阻断。虽然 icv 输注 NPY 不影响非社交和社交记忆的获得、巩固和检索，但 icv 输注 BIBO3304 三氟乙酸盐和 BIIE0246 阻断了非社交记忆的巩固和非社交和社交记忆的检索。这项研究表明，NPY 通过特异性作用于 Y1 受体在非社交环境中具有增强记忆的作用。它进一步表明，中枢 NPY 系统对非社交和社交记忆的连续阶段产生不同的影响。
