从珀金和卡罗重建紫红色的历史综合：程序和细节。

Reconstructing the historical synthesis of mauveine from Perkin and Caro: procedure and details.

机构信息

Coimbra Chemistry Centre, Department of Chemistry, University of Coimbra, P3004-535, Coimbra, Portugal.

出版信息

Sci Rep. 2017 Jul 28;7(1):6806. doi: 10.1038/s41598-017-07239-z.

DOI:10.1038/s41598-017-07239-z

PMID:28754965

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5533699/

Abstract

Mauveine, an iconic dye, first synthesised in 1856 still has secrets to unveil. If nowadays one wanted to prepare the original Perkin's mauveine, what would be the procedure? It will be described in this work and lies on the use of a 1:2:1 (mole) ratio of aniline, p-toluidine and o-toluidine. This was found from a comparison of a series of products synthesized from different proportions of these starting materials, with a set of historical samples of mauveine and further analysed with two unsupervised chemometrics methods.

摘要

洋红，一种标志性的染料，于 1856 年首次合成，至今仍有许多秘密有待揭示。如果现在有人想制备最初的珀金洋红，那么应该怎么做呢？本文将对此进行描述，具体方法是使用苯胺、对甲苯胺和邻甲苯胺以 1:2:1（摩尔比）进行反应。这是通过比较从这些起始原料的不同比例合成的一系列产物，以及一组洋红的历史样本，并使用两种无监督化学计量学方法进一步分析得出的。