Schulz H, Feuer L
Acta Physiol Hung. 1986;67(3):331-8.
The anticonflict properties of the anxiolytic diazepam and of the dipeptide Litoralon gamma-L-glutamyl-taurine and two of its analogues SZJ 3388, gamma-aminobutyryl-ethanolamine phosphate, and SZJ 3361, D-1-aminoisobutyrylethanolamine phosphate have been investigated in a "time-to-emerge" conflict paradigm in non-deprived rats. Diazepam, Litoralon and compound SZJ 3388 significantly decreased the "time-to-emerge" latency (TTE latency) in a dose-dependent manner versus saline- or vehicle-treated controls in doses between 0.05 and 0.50 mg/kg intraperitoneally. The analogue SZJ 3361 was inactive as regards the TTE latency, while the anti-histaminic promethazine lengthened the TTE latency in a dose-dependent manner. The number of irresolute responses was significantly decreased following administration of diazepam, SZJ 3388 and Litoralon and was positively correlated with the TEE latency-decreasing activity of these compounds. The data are discussed in terms of the benzodiazepine-like anxiolytic or anti-conflict properties of these dipeptides.
在未剥夺食物的大鼠“出现时间”冲突范式中，研究了抗焦虑药地西泮、二肽Litoralon（γ-L-谷氨酰-牛磺酸）及其两种类似物SZJ 3388（γ-氨基丁酰乙醇胺磷酸盐）和SZJ 3361（D-1-氨基异丁酰乙醇胺磷酸盐）的抗冲突特性。与腹腔注射0.05至0.50mg/kg剂量的生理盐水或赋形剂处理的对照组相比，地西泮、Litoralon和化合物SZJ 3388以剂量依赖性方式显著降低了“出现时间”潜伏期（TTE潜伏期）。类似物SZJ 3361对TTE潜伏期无活性，而抗组胺药异丙嗪以剂量依赖性方式延长了TTE潜伏期。给予地西泮、SZJ 3388和Litoralon后，犹豫不决反应的数量显著减少，且与这些化合物的TTE潜伏期降低活性呈正相关。根据这些二肽的苯二氮䓬类抗焦虑或抗冲突特性对数据进行了讨论。
