Schulz H, Feuer L, Pasics I
Acta Physiol Hung. 1985;65(2):169-79.
The effects of a single post-trial intraperitoneal administration of the dipeptide Litoralon (gamma-L-glutamyl-taurine) and some of its analogues were tested on the passive avoidance latency of male and female Wistar rats. The avoidance latency was significantly decreased by Litoralon and gamma-aminobutyryl-ethanolamine phosphate but lengthened by DL-beta-aminoisobutyryl-ethanolamine phosphate. No differences were observed between the responses of immature male and female rats following Litoralon treatment. The observed inter-group differences in passive avoidance behaviour following dipeptide administration were also demonstrable in tests of the open-field activity of the animals examined immediately after the 24-hour retention test. The results are discussed on the basis of a central Litoralon effect on emotional arousal and the anti-conflict potencies of the dipeptide.
通过对雄性和雌性Wistar大鼠进行单次试验后腹膜内注射二肽Litoralon（γ-L-谷氨酰-牛磺酸）及其一些类似物，测试了它们对被动回避潜伏期的影响。Litoralon和γ-氨基丁酰乙醇胺磷酸盐显著降低了回避潜伏期，但DL-β-氨基异丁酰乙醇胺磷酸盐则延长了回避潜伏期。在Litoralon处理后，未成熟雄性和雌性大鼠的反应之间未观察到差异。在24小时记忆测试后立即对所检查动物进行的旷场活动测试中，也证实了二肽给药后在被动回避行为上观察到的组间差异。根据Litoralon对情绪唤醒的中枢作用以及二肽的抗冲突效力对结果进行了讨论。
