Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.
Neuroimage. 2017 Oct 1;159:122-130. doi: 10.1016/j.neuroimage.2017.07.049. Epub 2017 Jul 26.
Episodic and spatial memory are commonly impaired in ageing and Alzheimer's disease. Volumetric and task-based functional magnetic resonance imaging (fMRI) studies suggest a preferential involvement of the medial temporal lobe (MTL), particularly the hippocampus, in episodic and spatial memory processing. The present study examined how these two memory types were related in terms of their associated resting-state functional architecture. 3T multiband resting state fMRI scans from 497 participants (60-82 years old) of the cross-sectional Whitehall II Imaging sub-study were analysed using an unbiased, data-driven network-modelling technique (FSLNets). Factor analysis was performed on the cognitive battery; the Hopkins Verbal Learning test and Rey-Osterreith Complex Figure test factors were used to assess verbal and visuospatial memory respectively. We present a map of the macroscopic functional connectome for the Whitehall II Imaging sub-study, comprising 58 functionally distinct nodes clustered into five major resting-state networks. Within this map we identified distinct functional connections associated with verbal and visuospatial memory. Functional anticorrelation between the hippocampal formation and the frontal pole was significantly associated with better verbal memory in an age-dependent manner. In contrast, hippocampus-motor and parietal-motor functional connections were associated with visuospatial memory independently of age. These relationships were not driven by grey matter volume and were unique to the respective memory domain. Our findings provide new insights into current models of brain-behaviour interactions, and suggest that while both episodic and visuospatial memory engage MTL nodes of the default mode network, the two memory domains differ in terms of the associated functional connections between the MTL and other resting-state brain networks.
情景和空间记忆在衰老和阿尔茨海默病中通常受损。容积和基于任务的功能磁共振成像 (fMRI) 研究表明，内侧颞叶（MTL），特别是海马体，优先参与情景和空间记忆处理。本研究探讨了这两种记忆类型在其相关静息态功能结构方面是如何相关的。使用无偏的、数据驱动的网络建模技术（FSLNets）分析了来自横断面 Whitehall II 成像子研究的 497 名参与者（60-82 岁）的 3T 多波段静息态 fMRI 扫描。对认知电池进行因子分析；使用霍普金斯词语学习测试和 Rey-Osterreith 复杂图形测试因子分别评估言语和视空间记忆。我们展示了 Whitehall II 成像子研究的宏观功能连接组图，该图包含 58 个功能上不同的节点，分为五个主要的静息态网络。在该图谱中，我们确定了与言语和视空间记忆相关的不同功能连接。海马体与额极之间的功能反相关与年龄相关的言语记忆呈显著正相关。相比之下，海马体-运动和顶叶-运动功能连接与视空间记忆相关，与年龄无关。这些关系不受灰质体积的影响，并且是各自记忆域所特有的。我们的研究结果为当前的大脑-行为相互作用模型提供了新的见解，并表明虽然情景和视空间记忆都涉及默认模式网络的 MTL 节点，但这两种记忆域在 MTL 和其他静息态大脑网络之间的相关功能连接方面存在差异。
