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猪细胞外基质在食管气管瘘修复术后复发性狭窄中的新应用。

Novel use of porcine extracellular matrix in recurrent stricture following repair of tracheoesophageal fistula.

作者信息

Cairo Sarah B, Tabak Benjamin, Harmon Carroll M, Bass Kathryn D

机构信息

Department of Pediatric Surgery, Women and Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA.

Department of Surgery, University at Buffalo, State University of New York School of Medicine and Bioscience, Buffalo, NY, USA.

出版信息

Pediatr Surg Int. 2017 Sep;33(9):1027-1033. doi: 10.1007/s00383-017-4130-3. Epub 2017 Jul 29.

DOI:10.1007/s00383-017-4130-3
PMID:28756526
Abstract

Anastomotic stricture is a common complication following repair of esophageal atresia (EA). Many factors are thought to contribute to stricture formation and a variety of management techniques have been developed. In this case report, we describe the treatment of a recurrent anastomotic stricture following repair of long-gap esophageal atresia. Porcine bladder extracellular matrix (ECM) was mounted on a stent and delivered endoscopically to the site of recurrent stricture. An appropriate positioning was confirmed using direct endoscopic visualization and intra-operative fluoroscopy. The patient recovered well with persistent radiographic and functional improvements in previous stricture.

摘要

吻合口狭窄是食管闭锁(EA)修复术后的常见并发症。许多因素被认为与狭窄形成有关,并且已经开发了多种治疗技术。在本病例报告中,我们描述了一例长间隙食管闭锁修复术后复发性吻合口狭窄的治疗。将猪膀胱细胞外基质(ECM)安装在支架上,并通过内镜输送至复发性狭窄部位。通过直接内镜观察和术中荧光透视确认了合适的位置。患者恢复良好,先前狭窄处的影像学和功能持续改善。

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本文引用的文献

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Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia.脱细胞材料作为长间隙食管闭锁组织工程研究的支架
Expert Opin Biol Ther. 2017 May;17(5):573-584. doi: 10.1080/14712598.2017.1308482. Epub 2017 Mar 27.
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Classification of Esophageal Strictures following Esophageal Atresia Repair.食管闭锁修复术后食管狭窄的分类
Eur J Pediatr Surg. 2018 Jun;28(3):243-249. doi: 10.1055/s-0037-1598656. Epub 2017 Mar 6.
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Routine post-operative esophagram Is not necessary after repair of esophageal atresia.
食管闭锁修复术后无需常规进行术后食管造影。
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In-vivo oesophageal regeneration in a human being by use of a non-biological scaffold and extracellular matrix.利用非生物支架和细胞外基质在人体内进行食管再生。
Lancet. 2016 Jul 2;388(10039):55-61. doi: 10.1016/S0140-6736(15)01036-3. Epub 2016 Apr 8.
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Repair of esophageal atresia with proximal fistula using endoscopic magnetic compression anastomosis (magnamosis) after staged lengthening.分期延长后使用内镜磁压缩吻合术(磁吻合术)修复食管闭锁合并近端瘘。
Pediatr Surg Int. 2016 May;32(5):525-8. doi: 10.1007/s00383-016-3889-y. Epub 2016 Mar 24.
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Risk Factors for Stricture Formation After Esophageal Atresia Repair.食管闭锁修复术后狭窄形成的危险因素
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J Pediatr Surg. 2015 Dec;50(12):2012-5. doi: 10.1016/j.jpedsurg.2015.08.015. Epub 2015 Aug 28.
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Revisional surgery for recurrent tracheoesophageal fistula and anastomotic complications after repair of esophageal atresia in 258 infants.258例食管闭锁修复术后复发性气管食管瘘及吻合口并发症的翻修手术
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