Telo Selda, Kırkıl Gamze, Kuluöztürk Mutlu, Balin Mehmet, Deveci Figen
Department of Biochemistry and Clinical Biochemistry, Firat University, School of Medicine (Firat Medical Center), Elazig 23119, Turkey.
Department of Chest Disease, Firat University, School of Medicine, (Firat Medical Center), Elazig 23119, Turkey.
Clin Respir J. 2018 Apr;12(4):1433-1438. doi: 10.1111/crj.12675. Epub 2017 Aug 11.
Asymmetric dimethylarginine (ADMA) decreases the levels of nitric oxide by inhibiting nitric oxide synthases. In this study, the possible role of ADMA in determining pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) patients was investigated.
Stable COPD patients who were admitted to pulmonology outpatient clinic were involved in the study. Forty healthy volunteers, with similar ages and sexes, were accepted as the control group. COPD patients were divided into two groups: 40 patients without PH (COPD group) and 40 COPD-related PH patients (COPD-PH group). Pulmonary function test, echocardiography and arterial blood analyses of all patients were performed.
The mean age of patients was 69.21 ± 10.62, and 15 of these patients were females. There was no significant difference between the two COPD groups in terms of age and sex (P > .05). There was no difference in PaO , SaO , FEV and FEV /FVC values between the two COPD groups (P > .05). Serum ADMA levels were similar in the control and the COPD group (0.42 ± 0.13 vs 0.43 ± 0.15), but it was significantly higher in the COPD-PH group compared to the control and the COPD group (0.49 ± 0.14). A negative correlation was determined between serum ADMA levels and SaO levels (r = -.247, P = .028). A significant positive correlation observed between ADMA and systolic pulmonary artery pressure values (r = .627, P < .001) CONCLUSIONS: In conclusion, high levels of serum ADMA levels may be able to determine the presence of PH.
不对称二甲基精氨酸（ADMA）通过抑制一氧化氮合酶降低一氧化氮水平。本研究调查了ADMA在慢性阻塞性肺疾病（COPD）患者肺动脉高压（PH）发生中的可能作用。
纳入呼吸内科门诊收治的稳定期COPD患者。40名年龄和性别匹配的健康志愿者作为对照组。COPD患者分为两组：40例无PH的患者（COPD组）和40例COPD相关PH患者（COPD-PH组）。对所有患者进行肺功能检查、超声心动图检查和动脉血气分析。
患者的平均年龄为69.21±10.62岁，其中15例为女性。两组COPD患者在年龄和性别方面无显著差异（P>.05）。两组COPD患者的动脉血氧分压（PaO）、动脉血氧饱和度（SaO）、第一秒用力呼气容积（FEV）和FEV/用力肺活量（FVC）值无差异（P>.05）。对照组和COPD组的血清ADMA水平相似（0.42±0.13 vs 0.43±0.15），但COPD-PH组的血清ADMA水平显著高于对照组和COPD组（0.49±0.14）。血清ADMA水平与SaO水平呈负相关（r=-.247，P=.028）。ADMA与收缩期肺动脉压值呈显著正相关（r=.627，P<.001）。结论：总之，血清ADMA水平升高可能与PH的发生有关。
