Hewes Jenny L, Lee Ji Young, Fagan Karen A, Bauer Natalie N
Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Pulm Circ. 2020 Feb 4;10(1):2045894019892801. doi: 10.1177/2045894019892801. eCollection 2020 Jan-Mar.
Pulmonary hypertension is a complex, multifactorial disease that results in right heart failure and premature death. Since the initial reports of pulmonary hypertension in the late 1800s, the diagnosis of pulmonary hypertension has evolved with respect to its definition, screening tools, and diagnostic techniques. This historical perspective traces the earliest roots of pulmonary hypertension detection and diagnosis through to the current recommendations for classification. We highlight the diagnostic tools used in the past and present, and end with a focus on the future directions of early detection. Early detection of pulmonary hypertension and pulmonary arterial hypertension and the proper determination of etiology are vital for the early therapeutic intervention that can prolong life expectancy and improve quality of life. The search for a non-invasive screening tool for the identification and classification of pulmonary hypertension is ongoing, and we discuss the role of animal models of the disease in this search.
肺动脉高压是一种复杂的多因素疾病，可导致右心衰竭和过早死亡。自19世纪末首次报道肺动脉高压以来，肺动脉高压的诊断在定义、筛查工具和诊断技术方面不断发展。这一历史视角追溯了肺动脉高压检测和诊断的最早根源，直至当前的分类建议。我们重点介绍了过去和现在使用的诊断工具，并以对早期检测未来方向的关注作为结尾。早期检测肺动脉高压和肺动脉高压并正确确定病因对于能够延长预期寿命和改善生活质量的早期治疗干预至关重要。寻找一种用于识别和分类肺动脉高压的非侵入性筛查工具的工作正在进行中，我们讨论了该疾病动物模型在这一探索中的作用。
