Moldovan Radu-Cristian, Bodoki Ede, Servais Anne-Catherine, Crommen Jacques, Oprean Radu, Fillet Marianne
Laboratory for the Analysis of Medicines, Department of Pharmacy, Faculty of Medicine, CIRM, University of Liege,Avenue Hippocrate 15, B36-+3-T4, 4000 Liege, Belgium; Department of Analytical Chemistry and Instrumental Analysis, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca,4 Louis Pasteur street, 400349 Cluj-Napoca, Romania.
Department of Analytical Chemistry and Instrumental Analysis, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca,4 Louis Pasteur street, 400349 Cluj-Napoca, Romania.
J Chromatogr A. 2017 Sep 1;1513:1-17. doi: 10.1016/j.chroma.2017.07.045. Epub 2017 Jul 16.
Over the last 30years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related to the state of the art in FLEC labeling and subsequent chiral separation of the resulting diastereomers using LC, SFC and CE techniques.
在过去30年里，（±）-1-（9-芴基）乙基氯甲酸酯（（±）-FLEC）在各种分析应用中用作手性衍生化试剂，这些应用涉及多种内源性、药物性和与环境相关的分子。本综述旨在介绍与FLEC标记以及随后使用液相色谱（LC）、超临界流体色谱（SFC）和毛细管电泳（CE）技术对手性异构体进行手性分离的最新技术相关的所有重要方面。
