Pilotte Nils, Unnasch Thomas R, Williams Steven A
Department of Biological Sciences, Smith College, Northampton, MA, USA; Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA, USA; These authors contributed equally to this work.
Department of Global Health, University of South Florida, Tampa, FL, USA; These authors contributed equally to this work.
Trends Parasitol. 2017 Oct;33(10):788-798. doi: 10.1016/j.pt.2017.06.008. Epub 2017 Jul 27.
The capacity of vector insect surveillance to provide estimates of pathogen prevalence and transmission potential has long been recognized within the global communities tasked with eliminating lymphatic filariasis (LF), the underlying cause of elephantiasis and hydrocele, and onchocerciasis (river blindness). Initially restricted to the practice of dissection, the potential of vector monitoring has grown due to the advent of molecular methods capable of increasing the sensitivity and throughput of testing. However, despite such advancement, operational research gaps remain. If insufficiently addressed, these gaps will reduce the utility of molecular xenomonitoring (MX) for onchocerciasis as elimination efforts expand into Africa. Similarly, such shortcomings will limit the programmatic usefulness of MX for LF, resulting in this technique's significant underutilization.
病媒昆虫监测在提供病原体流行率和传播潜力估计方面的能力，早已在致力于消除象皮肿和鞘膜积液的根本病因淋巴丝虫病（LF）以及盘尾丝虫病（河盲症）的全球社区中得到认可。病媒监测最初仅限于解剖实践，随着能够提高检测灵敏度和通量的分子方法的出现，病媒监测的潜力得到了提升。然而，尽管有这样的进展，仍存在业务研究差距。如果这些差距得不到充分解决，随着消除努力扩展到非洲，这些差距将降低分子异体监测（MX）在盘尾丝虫病防治中的效用。同样，这些不足也将限制MX在LF防治中的计划实用性，导致这项技术未得到充分利用。
