AGO介导的RNA沉默的结构基础
Structural Foundations of RNA Silencing by Argonaute.
作者信息
Sheu-Gruttadauria Jessica, MacRae Ian J
机构信息
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
J Mol Biol. 2017 Aug 18;429(17):2619-2639. doi: 10.1016/j.jmb.2017.07.018. Epub 2017 Jul 27.
Abstract
Nearly every cell in the human body contains a set of programmable gene-silencing proteins named Argonaute. Argonaute proteins mediate gene regulation by small RNAs and thereby contribute to cellular homeostasis during diverse physiological process, such as stem cell maintenance, fertilization, and heart development. Over the last decade, remarkable progress has been made toward understanding Argonaute proteins, small RNAs, and their roles in eukaryotic biology. Here, we review current understanding of Argonaute proteins from a structural prospective and discuss unanswered questions surrounding this fascinating class of enzymes.
摘要
人体中几乎每个细胞都含有一组名为Argonaute的可编程基因沉默蛋白。Argonaute蛋白通过小RNA介导基因调控，从而在多种生理过程（如干细胞维持、受精和心脏发育）中促进细胞稳态。在过去十年中，我们对Argonaute蛋白、小RNA及其在真核生物生物学中的作用的理解取得了显著进展。在这里，我们从结构角度综述了目前对Argonaute蛋白的理解，并讨论了围绕这类迷人酶的未解决问题。
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