Lamblin G, Thiberville G, Bansac Lamblin A, Moret S, Du-Mesnildot P, Rannou C, Ploton I, Chabert P, Chene G
Département de chirurgie gynécologique, Femme-Mère-Enfant hospital, 69000 Lyon-Bron, France.
Département de radiologie, Centre lyonnais imagerie féminine, 69000 Lyon, France.
Gynecol Obstet Fertil Senol. 2017 Sep;45(9):453-459. doi: 10.1016/j.gofs.2017.06.017. Epub 2017 Jul 27.
To compare ovarian function before and after laparoscopic hysterectomy with bilateral salpingectomy for benign lesions with two different systems of haemostasis.
In this prospective randomized study comparing two types of energy used for coagulation in bilateral salpingectomy (group A: bipolar electric energy, versus group B: ultrasonic advanced energy [Harmonic]), forty consecutive non-menopausal patients undergoing laparoscopic hysterectomy for benign lesions were included. Values of anti-Müllerian hormone (AMH), LH and FSH, antral follicle count (AFC) and ovarian vascularization on bilateral Doppler ultrasound, quality of life (questionnaire) were assessed preoperatively and at 1 and 3 months postoperatively.
Preliminary analysis showed shorter salpingectomy operating time (P<0.0001) and less bleeding (P<0.005) in group B. In group A, there was no statistical difference except a decrease in AFC at 1 and 3 months on the right ovary (P=0.04). In group B, AMH levels were significantly lower postoperatively at 3 months and LH levels were increased at 3 months (respectively P=0.02 et P=0.04). There was no statistical difference in the ultrasonographic data. Quality of life did not significantly differ in both groups.
Preliminary findings showed reduced AMH levels at 3months postoperatively in ultrasonic energy group whereas there was no significative menopausal symptoms. It seems important to continue this study in order to know the real effects of both energy systems on the ovarian function.
比较两种不同止血系统用于腹腔镜子宫切除术联合双侧输卵管切除术治疗良性病变前后的卵巢功能。
在这项前瞻性随机研究中,比较双侧输卵管切除术中两种用于凝血的能量类型(A组:双极电能,B组:超声高级能量[谐波]),纳入了40例因良性病变接受腹腔镜子宫切除术的连续非绝经患者。术前及术后1个月和3个月评估抗苗勒管激素(AMH)、促黄体生成素(LH)和促卵泡生成素(FSH)的值、窦卵泡计数(AFC)以及双侧多普勒超声检查的卵巢血管化情况,通过问卷调查评估生活质量。
初步分析显示,B组的输卵管切除术手术时间较短(P<0.0001)且出血较少(P<0.005)。在A组中,除右侧卵巢在术后1个月和3个月时AFC有所下降外(P=0.04),无统计学差异。在B组中,术后3个月时AMH水平显著降低,LH水平在3个月时升高(分别为P=0.02和P=0.04)。超声数据无统计学差异。两组的生活质量无显著差异。
初步研究结果显示,超声能量组术后3个月时AMH水平降低,但无明显的绝经症状。继续开展这项研究以了解两种能量系统对卵巢功能的实际影响似乎很重要。