Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, National Cancer Institute "Giovanni Paolo II", Bari, Italy.
Immunol Lett. 2017 Oct;190:58-63. doi: 10.1016/j.imlet.2017.07.014. Epub 2017 Jul 27.
Natural Killer (NK) cells were discovered when research on T cells produced an unexplained background, or "natural" cytotoxicity in non-immunized mice. The previously unknown cells were thus named "natural" killer cells, or NK cells. They are roughly defined by a lack of the T cell marker CD3 and a presence of CD56 (or NCAM, neural cell adhesion molecule) and correspond to the large granular lymphocytes (LGLs). This article is focused to the description the morphological features of these cells and of the LGLs and to the fundamental contribution of the Italian scientist Carlo E. Grossi to the ultrastructural characterization of these cells.
自然杀伤 (NK) 细胞是在研究 T 细胞时发现的，在未免疫的小鼠中产生了一种无法解释的背景或“天然”细胞毒性。因此，这些以前未知的细胞被命名为“自然”杀伤细胞，或 NK 细胞。它们大致被定义为缺乏 T 细胞标志物 CD3 和存在 CD56（或 NCAM，神经细胞黏附分子），并对应于大颗粒淋巴细胞 (LGL)。本文重点描述了这些细胞和 LGL 的形态特征，以及意大利科学家卡罗·E·格罗西 (Carlo E. Grossi) 对这些细胞的超微结构特征描述的基础性贡献。
