诸多恶疾之源：惰性大颗粒淋巴细胞白血病及相关疾病。
The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders.
机构信息
Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
出版信息
Hematol Oncol. 2010 Sep;28(3):105-17. doi: 10.1002/hon.917.
Abstract
Large granular lymphocytes (LGL) leukaemia can arise from either natural killer (NK) cells or cytotoxic T lymphocytes (CTL). The T-cell form of LGL leukaemia has significant overlap with other haematological disorders and autoimmune diseases. Here we provide an overview of LGL biology. We also focus discussion on the indolent LGL leukaemia related disorders and their causal relationships. We then discuss the potential relationships and distinctions between indolent LGL leukaemia and non-malignant clonal lymphocyte expansion that occur in otherwise healthy individuals, especially elder people.
摘要
大颗粒淋巴细胞（LGL）白血病可来源于自然杀伤（NK）细胞或细胞毒性 T 淋巴细胞（CTL）。LGL 白血病的 T 细胞形式与其他血液系统疾病和自身免疫性疾病有很大的重叠。在这里，我们提供了 LGL 生物学的概述。我们还重点讨论了惰性 LGL 白血病相关疾病及其因果关系。然后，我们讨论了惰性 LGL 白血病与在其他健康个体中发生的非恶性克隆性淋巴细胞扩增之间的潜在关系和区别，特别是老年人。
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