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“自助餐”大鼠肝脏和肌肉中氨基酸代谢酶的产后发育

Postnatal development of amino acid metabolism enzymes in the liver and muscle of 'cafeteria' rats.

作者信息

Salvadó J, Arola L, Alemany M

出版信息

Biochem Int. 1986 Jul;13(1):115-21.

PMID:2875717
Abstract

The effect of feeding a high-energy highly palatable cafeteria diet on the liver and muscle ontogenesis of serine dehydratase, alanine transaminase, glutamine synthetase and adenylate deaminase during postnatal development of the rat has been studied. The results are in agreement with the lower amino acid utilization in cafeteria rats, both adults and during postnatal development. The feeding of excess energy coupled with high-quality protein resulted in changes in the ontogenesis of the studied enzymes that coincide with the development of protein synthesis and overall pup growth even before they had direct access to this rich diet, suggesting that cafeteria feeding already affects the amino acid metabolism of the pup through the dam's milk.

摘要

研究了喂食高能高适口性自助餐厅式饮食对大鼠出生后发育过程中肝脏和肌肉中丝氨酸脱水酶、丙氨酸转氨酶、谷氨酰胺合成酶和腺苷酸脱氨酶发生的影响。结果与自助餐厅式饮食喂养的大鼠(包括成年大鼠和出生后发育阶段的大鼠)中较低的氨基酸利用率一致。喂食过量能量并搭配优质蛋白质导致所研究酶的发生变化,这些变化甚至在幼崽直接接触这种丰富饮食之前就与蛋白质合成的发展和幼崽的整体生长相吻合,这表明自助餐厅式饮食喂养已经通过母鼠的乳汁影响幼崽的氨基酸代谢。

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Biochem Int. 1986 Jul;13(1):115-21.
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