Mangal Anil, Shubhasree M N, Devi Pramila, Jadhav A D, Prasad Sai A, Kumar Kisore, Otta Sarada, Dhiman K S
National Research Institute for Ayurveda Siddha Human Resource Development (NRIASHRD), Central Council for Research in Ayurvedic Sciences, Gwalior, Madhya Pradesh, India.
National Ayurveda Dietetics Research Institute (NADRI), Central Council for Research in Ayurvedic Sciences, Bangalore, Karnataka, India.
J Ayurveda Integr Med. 2017 Jul-Sep;8(3):200-204. doi: 10.1016/j.jaim.2017.02.001. Epub 2017 Jul 28.
In present era, pharmacological, bio-chemical and surgical interventions are not success remedy for Osteoarthritis (OA). Ayurveda and other complementary medicine have medication for OA.
The main aim of the study was to assess the efficacy and safety of therapeutic combination of Vatari guggulu along with Maharasnadi kwatha and Narayan taila with gentle massage for 15 min daily up to 12 weeks on affected knee joint pain assessed on Visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
It was an open label, multicentre, prospective, clinical study conducted on 142 patients of OA Knee. Vatari guggulu 500 mg thrice in a day along with Maharasnadi kwatha 20 ml with equal amount of water twice daily and Narayan taila 20 ml twice in a day for external application with gentle massage for 15 min up to 12 weeks were used to all the study participants.
VAS, WOMAC score and clinical symptoms were reduced significantly from baseline to end of the treatment (P < 0.001).
The study provides good evidence in support of the efficacy and safety of the Vatari guggulu along with Maharasnadi kwatha and Narayan taila in the management of Osteoarthritis knee.
在当今时代，药理学、生物化学和外科干预并非治疗骨关节炎（OA）的成功疗法。阿育吠陀医学和其他补充医学有针对OA的药物。
本研究的主要目的是评估瓦塔里古古卢（Vatari guggulu）、玛哈拉斯纳迪夸塔（Maharasnadi kwatha）和那拉亚纳油（Narayan taila）联合治疗，并每天在患膝关节进行15分钟轻柔按摩，持续12周，对采用视觉模拟量表（VAS）和西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评估的患膝关节疼痛的疗效和安全性。
这是一项对142例膝骨关节炎患者进行的开放标签、多中心、前瞻性临床研究。所有研究参与者均使用瓦塔里古古卢500毫克，每日三次，同时服用玛哈拉斯纳迪夸塔20毫升，加等量水，每日两次，以及那拉亚纳油20毫升，每日两次，用于外用并轻柔按摩15分钟，持续12周。
从基线到治疗结束，VAS、WOMAC评分和临床症状均显著降低（P < 0.001）。
该研究为瓦塔里古古卢、玛哈拉斯纳迪夸塔和那拉亚纳油联合治疗膝骨关节炎的疗效和安全性提供了有力证据。
