Hu Li-qiao, Zhou Zhao-cai, Tian Wei
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Yi Chuan. 2017 Jul 20;39(7):659-674. doi: 10.16288/j.yczz.17-062.
The Hippo signaling pathway has been identified to be involved in development and tissue homeostasis during the past decade, and is evolutionarily conserved from Drosophila to mammals. It transduces the signal through a series of protein-protein interaction and kinase cascades, to control the cell number and organ size by inhibiting cell proliferation and promoting apoptosis. Dysregulation of the Hippo signaling pathway is associated with tumorigenesis and cancers, so it is a crucial target for cancer therapy and regeneration medicine. Most of the Hippo signaling pathway components have been identified, and the cellular function and molecular mechanism have been revealed by structural and functional researches. In this review, we summarize the molecular structure of Hippo signaling pathway components and related targeting inhibitors from a structural view. We hope to improve the understandings of the regulation mechanism of the Hippo signaling transduction, and facilitate further functional studies and potential therapeutic interventions.
在过去十年中，河马信号通路已被确定参与发育和组织稳态，并且从果蝇到哺乳动物在进化上是保守的。它通过一系列蛋白质-蛋白质相互作用和激酶级联来转导信号，通过抑制细胞增殖和促进细胞凋亡来控制细胞数量和器官大小。河马信号通路的失调与肿瘤发生和癌症相关，因此它是癌症治疗和再生医学的关键靶点。大多数河马信号通路成分已被确定，并且通过结构和功能研究揭示了其细胞功能和分子机制。在本综述中，我们从结构角度总结了河马信号通路成分的分子结构和相关靶向抑制剂。我们希望增进对河马信号转导调控机制的理解，并促进进一步的功能研究和潜在的治疗干预。
