Yao Chuan-bo, Zhou Xin, Chen Ce-shi, Lei Qun-ying
Cancer Institute, Fudan University Shanghai Cancer Center and Cancer Metabolism Laboratory of Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Yi Chuan. 2017 Jul 20;39(7):617-629. doi: 10.16288/j.yczz.17-100.
Hippo signaling pathway has attracted broad attention due to its essential roles in controlling organ size and tumorigenesis. TAZ/YAP, two core downstream molecules of the Hippo signaling pathway in mammals, are tightly regulated by a wide range of extracellular and intrinsic signals in both Hippo signaling pathway-dependent and -independent manners. Besides their roles in the development and function of normal mammary glands, TAZ/YAP display remarkable potency and relevance to multiple aspects of human breast carcinogenesis, including cellular proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition and stemness. In this review, we summarize the regulators of TAZ/YAP, discuss the significant contribution of the Hippo signaling pathway to human breast cancers and highlight their potential therapeutic roles.
由于在控制器官大小和肿瘤发生中起关键作用，河马信号通路已引起广泛关注。TAZ/YAP是哺乳动物河马信号通路的两个核心下游分子，在依赖和不依赖河马信号通路的情况下，受到多种细胞外和内在信号的严格调控。除了在正常乳腺的发育和功能中发挥作用外，TAZ/YAP在人类乳腺癌的多个方面，包括细胞增殖、分化、凋亡、迁移、侵袭、上皮-间质转化和干性，都表现出显著的作用和相关性。在这篇综述中，我们总结了TAZ/YAP的调节因子，讨论了河马信号通路对人类乳腺癌的重要贡献，并强调了它们潜在的治疗作用。
