多巴胺调节大鼠视网膜神经元与肌肉细胞形成的胆碱能突触处的诱发传递。

Dopamine modulates evoked transmission at cholinergic synapses formed by rat retinal neurons with muscle cells.

作者信息

Tsai W H, Puro D G

出版信息

Brain Res. 1986 Aug 20;380(2):375-8. doi: 10.1016/0006-8993(86)90239-8.

Abstract

The purpose of this study was to investigate the effect of dopamine on synaptic transmission mediated by cholinergic neurons derived from the rat retina. We used a cell culture system that permitted the physiological monitoring of acetylcholine released at synapses formed between retinal neurons and striated muscle cells. Dopamine was found to facilitate evoked transmission by a mechanism mediated by D1 dopamine receptors. The results support the hypothesis that dopamine may have a modulatory role in information processing by the mammalian retina.

摘要

本研究的目的是调查多巴胺对源自大鼠视网膜的胆碱能神经元介导的突触传递的影响。我们使用了一种细胞培养系统，该系统能够对视网膜神经元与横纹肌细胞之间形成的突触处释放的乙酰胆碱进行生理学监测。发现多巴胺通过由D1多巴胺受体介导的机制促进诱发传递。这些结果支持了多巴胺可能在哺乳动物视网膜的信息处理中具有调节作用这一假说。