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治疗性低温对溺水儿童的神经学预后有积极影响。

Therapeutic hypothermia brings favorable neurologic outcomes in children with near drowning.

作者信息

Chen Ming-Chun, Chu Chia-Hsiang, Cheng Ching-Feng, Lin Jun-Song, Chen Jui-Hsia, Chang Yu-Hsun

机构信息

Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Department of Medicine, Tzu Chi University, Hualien, Taiwan.

出版信息

Tzu Chi Med J. 2016 Oct-Dec;28(4):180-182. doi: 10.1016/j.tcmj.2016.07.003. Epub 2016 Sep 15.

DOI:10.1016/j.tcmj.2016.07.003
PMID:28757754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5442905/
Abstract

A 1-year-10-month-old boy was admitted to our pediatric intensive care unit due to near drowning with pulmonary edema. A conventional ventilator with 100% oxygen supplementation was used initially, but was shifted to high frequency oscillatory ventilation as his oxygen saturation was around 84-88%. Therapeutic hypothermia was applied due to hypoxic ischemic encephalopathy with severe acidosis. His respiratory condition improved and he was extubated successfully on the 6 hospital day. The patient had no obvious neurological defects and he was discharged in a stable condition after 17 days of hospitalization. Our case report demonstrates the advantages of therapeutic hypothermia on survival and neurological outcomes in treating pediatric near drowning patients.

摘要

一名1岁10个月大的男孩因近乎溺水伴肺水肿入住我们的儿科重症监护病房。最初使用常规呼吸机并补充100%的氧气,但由于其血氧饱和度在84%-88%左右,随后改为高频振荡通气。因缺氧缺血性脑病伴严重酸中毒而进行了治疗性低温治疗。他的呼吸状况改善,在住院第6天成功拔管。该患者没有明显的神经功能缺陷,住院17天后病情稳定出院。我们的病例报告证明了治疗性低温治疗对小儿近乎溺水患者生存及神经功能转归的益处。

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本文引用的文献

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Asystolic cardiac arrest from near drowning managed with therapeutic hypothermia.低温治疗用于处理近乎溺亡导致的心脏停搏。
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Therapeutic hypothermia for traumatic brain injury.创伤性脑损伤的治疗性低温。
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Resuscitation. 2012 Sep;83(9):1078-84. doi: 10.1016/j.resuscitation.2012.05.009. Epub 2012 May 24.
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Clinical experience of extracorporeal membrane oxygenation for acute respiratory distress syndrome associated with pneumonia in children.儿童肺炎相关性急性呼吸窘迫综合征体外膜肺氧合的临床经验。
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Recovery from near drowning and postanoxic status epilepticus with controlled hypothermia.通过控制性低温治疗从近乎溺水和缺氧后癫痫持续状态中恢复。
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Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia Pediatric Head Injury Trial.严重创伤性脑损伤后接受低温治疗的儿童中低血压和低脑灌注压对结局的影响:儿科颅脑损伤低温治疗试验的事后分析。
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Hypoxic-ischaemic brain injury.缺氧缺血性脑损伤
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Induced hypothermia for trauma: current research and practice.创伤后低温诱导:当前研究与实践。
J Intensive Care Med. 2010 Jul;25(4):205-26. doi: 10.1177/0885066610366919. Epub 2010 May 5.
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Induction and maintenance of therapeutic hypothermia after pediatric cardiac arrest: efficacy of a surface cooling protocol.小儿心脏骤停后治疗性低温的诱导与维持:一种体表降温方案的疗效
Pediatr Crit Care Med. 2011 May;12(3):e127-35. doi: 10.1097/PCC.0b013e3181e28717.
10
Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children.治疗性低温可在婴幼儿严重创伤性脑损伤后维持抗氧化防御功能。
Crit Care Med. 2009 Feb;37(2):689-95. doi: 10.1097/CCM.0b013e318194abf2.