Salehi-Nik Nasim, Rezai Rad Maryam, Kheiri Lida, Nazeman Pantea, Nadjmi Nasser, Khojasteh Arash
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Stem Cells Int. 2017;2017:8354640. doi: 10.1155/2017/8354640. Epub 2017 Jul 5.
Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuses on the characteristics and osteogenic capability of stem cells derived from BFP as a valuable cell source for bone tissue engineering. An electronic search was performed on all in vitro and in vivo studies that used stem cells from BFP for the purpose of bone tissue engineering from 2010 until 2016. This review was organized according to the PRISMA statement. Adipose-derived stem cells derived from BFP (BFPSCs) were compared with adipose tissues from other parts of the body (AdSCs). Moreover, the osteogenic capability of dedifferentiated fat cells (DFAT) derived from BFP (BFP-DFAT) has been reported in comparison with BFPSCs. BFP is an easily accessible source of stem cells that can be obtained via the oral cavity without injury to the external body surface. Comparing BFPSCs with AdSCs indicated similar cell yield, morphology, and multilineage differentiation. However, BFPSCs proliferate faster and are more prone to producing colonies than AdSCs.
脂肪组织在骨组织工程中具有巨大潜力，因为它们作为一种废弃物大量存在。颊脂垫（BFP）是一种特殊的脂肪组织，易于获取且血供丰富，其获取对患者造成的并发症较少。本综述聚焦于源自BFP的干细胞作为骨组织工程有价值细胞来源的特性和成骨能力。对2010年至2016年期间所有使用源自BFP的干细胞进行骨组织工程的体外和体内研究进行了电子检索。本综述按照PRISMA声明进行组织。将源自BFP的脂肪干细胞（BFPSCs）与身体其他部位的脂肪组织（AdSCs）进行了比较。此外，还报道了源自BFP的去分化脂肪细胞（BFP-DFAT）与BFPSCs相比的成骨能力。BFP是一种易于获取的干细胞来源，可通过口腔获得而不会损伤体表。将BFPSCs与AdSCs比较表明，二者细胞产量、形态和多向分化相似。然而，BFPSCs比AdSCs增殖更快且更易于形成集落。
