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MicroRNA in osteoarthritis.骨关节炎中的微小RNA
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Significant Changes in Serum MicroRNAs after High Tibial Osteotomy in Medial Compartmental Knee Osteoarthritis: Potential Prognostic Biomarkers.内侧间室膝关节骨关节炎高位胫骨截骨术后血清微小RNA的显著变化：潜在的预后生物标志物
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本文引用的文献

1
Upregulation of microRNA-125b-5p is involved in the pathogenesis of osteoarthritis by downregulating SYVN1.微小RNA-125b-5p的上调通过下调SYVN1参与骨关节炎的发病机制。
Oncol Rep. 2017 Apr;37(4):2490-2496. doi: 10.3892/or.2017.5475. Epub 2017 Feb 24.
2
Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway.miR-221-3p的下调通过直接靶向SDF1/CXCR4信号通路促进白细胞介素-1β诱导的软骨降解。
J Mol Med (Berl). 2017 Jun;95(6):615-627. doi: 10.1007/s00109-017-1516-6. Epub 2017 Feb 24.
3
Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2.关节内注射抗 miR-483-5p 通过调节 Matrilin 3 和金属蛋白酶组织抑制剂 2 抑制骨关节炎。
Mol Ther. 2017 Mar 1;25(3):715-727. doi: 10.1016/j.ymthe.2016.12.020. Epub 2017 Jan 27.
4
Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway.静水压通过Wnt/β-连环蛋白信号通路调节骨关节炎软骨细胞培养物中的微小RNA表达水平。
Int J Mol Sci. 2017 Jan 12;18(1):133. doi: 10.3390/ijms18010133.
5
Effects of miR-145 on the inhibition of chondrocyte proliferation and fibrosis by targeting TNFRSF11B in human osteoarthritis.miR-145通过靶向TNFRSF11B对人骨关节炎软骨细胞增殖和纤维化的抑制作用
Mol Med Rep. 2017 Jan;15(1):75-80. doi: 10.3892/mmr.2016.5981. Epub 2016 Dec 5.
6
MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation.微小RNA-92a-3p通过在软骨形成和降解过程中直接靶向组蛋白去乙酰化酶2来调节软骨特异性基因的表达。
Osteoarthritis Cartilage. 2017 Apr;25(4):521-532. doi: 10.1016/j.joca.2016.11.006. Epub 2016 Nov 21.
7
Silencing of microRNA-138-5p promotes IL-1β-induced cartilage degradation in human chondrocytes by targeting FOXC1: miR-138 promotes cartilage degradation.微小RNA-138-5p的沉默通过靶向FOXC1促进白细胞介素-1β诱导的人软骨细胞软骨降解：微小RNA-138促进软骨降解。
Bone Joint Res. 2016 Oct;5(10):523-530. doi: 10.1302/2046-3758.510.BJR-2016-0074.R2.
8
MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes.微小RNA-9通过软骨细胞中的核因子κB1途径调节膝骨关节炎的发展。
Medicine (Baltimore). 2016 Sep;95(36):e4315. doi: 10.1097/MD.0000000000004315.
9
MiR-98 promotes chondrocyte apoptosis by decreasing Bcl-2 expression in a rat model of osteoarthritis.在骨关节炎大鼠模型中，miR-98通过降低Bcl-2表达促进软骨细胞凋亡。
Acta Biochim Biophys Sin (Shanghai). 2016 Oct;48(10):923-929. doi: 10.1093/abbs/gmw084. Epub 2016 Sep 2.
10
MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression.微小RNA-381通过抑制组蛋白去乙酰化酶4的表达来调节软骨细胞肥大。
Int J Mol Sci. 2016 Aug 23;17(9):1377. doi: 10.3390/ijms17091377.

微小RNA在骨关节炎中的作用。

Role of MicroRNA in Osteoarthritis.

作者信息

Zhang Mingcai, Lygrisse Kate, Wang Jinxi

机构信息

Harrington Laboratory for Molecular Orthopedics, Department of Orthopedic Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.

Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA.

出版信息

J Arthritis. 2017 Apr;6(2). doi: 10.4172/2167-7921.1000239. Epub 2017 Apr 28.

DOI:10.4172/2167-7921.1000239
PMID:28758052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5533289/
Abstract

Although the potential effect of aberrant expression of catabolic and anabolic genes on the development of osteoarthritis (OA) is well-documented, the regulatory mechanism for the expression of these genes in articular chondrocytes remains to be elucidated. The recent advances in epigenetic studies have identified microRNA (miRNA) as one of the epigenetic mechanisms for the regulation of gene expression. This mini review highlights the role of miRNA in the regulation of gene expression in articular chondrocytes and its significance in the pathogenesis of OA, with a discussion on the potential of miRNA as a new biomarker and therapeutic target for OA. Further investigations are required to determine the specificity, sensitivity, and efficacy of miRNA for clinical applications.

摘要

尽管分解代谢和合成代谢基因的异常表达对骨关节炎（OA）发展的潜在影响已有充分记录，但这些基因在关节软骨细胞中表达的调控机制仍有待阐明。表观遗传学研究的最新进展已将微小RNA（miRNA）确定为基因表达调控的表观遗传机制之一。本综述重点介绍了miRNA在关节软骨细胞基因表达调控中的作用及其在OA发病机制中的意义，并讨论了miRNA作为OA新生物标志物和治疗靶点的潜力。需要进一步研究以确定miRNA在临床应用中的特异性、敏感性和疗效。