Park Dayun, Lee Ho Jun, Lee Kwang Hoon, Kwon Bum Sun, Park Jin-Woo, Nam Ki Yeun, Lee Kyoung Hwan
Department of Physical Medicine and Rehabilitation, Dongguk University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Dongguk University College of Medicine, Seoul, Korea.
Ann Rehabil Med. 2017 Jun;41(3):493-497. doi: 10.5535/arm.2017.41.3.493. Epub 2017 Jun 29.
Churg-Strauss syndrome (CSS) is a rare systemic vasculitis that affect small and medium-sized blood vessels and is accompanied by asthma, eosinophilia, and peripheral neuropathy. This report describes a case of a 52-year-old man who had a history of sinusitis, asthma, and thymus cancer and who had complained of bilateral lower extremity paresthesia and weakness for a month. Peripheral neuropathy was detected by electrodiagnostic studies. Resection of a mediastinal mass, which was diagnosed as thymic neuroendocrine carcinoma, was performed five months before his visit. After thymectomy, peripheral blood tests revealed a gradual increase in eosinophils. Two months after surgery, he was admitted to the hospital for dyspnea, and nodules of focal consolidation were found in his chest X-ray. One month later, pyoderma occurred in the right shin, and the skin biopsy showed extravascular eosinophilic infiltration. He was diagnosed with CSS after thymectomy, and we report a very rare case of CSS presented with thymic neuroendocrine carcinoma.
变应性肉芽肿性血管炎（CSS）是一种罕见的系统性血管炎，累及中小血管，并伴有哮喘、嗜酸性粒细胞增多和周围神经病变。本报告描述了一例52岁男性患者，有鼻窦炎、哮喘和胸腺癌病史，主诉双侧下肢感觉异常和无力1个月。通过电诊断检查发现周围神经病变。在其就诊前5个月，对诊断为胸腺神经内分泌癌的纵隔肿块进行了切除。胸腺切除术后，外周血检查显示嗜酸性粒细胞逐渐增多。术后2个月，他因呼吸困难入院，胸部X线检查发现局灶性实变结节。1个月后，右小腿出现脓皮病，皮肤活检显示血管外嗜酸性粒细胞浸润。胸腺切除术后他被诊断为CSS，我们报告了一例非常罕见的以胸腺神经内分泌癌为表现的CSS病例。
