Hornby Natasha L, Lamb Christopher R
Department of Clinical Sciences and Services, The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA, UK.
Vet Radiol Ultrasound. 2017 Nov;58(6):647-652. doi: 10.1111/vru.12532. Epub 2017 Jul 30.
In computed tomographic (CT) images of humans, decreased lung attenuation, bronchial dilation, and/or thickening, air trapping, cysts, and thickened interlobular septa have been associated with increasing age. To determine if there are differences in the CT appearance of the lungs of young and old dogs that could affect interpretation of diagnostic studies, pulmonary CT images of dogs with conditions unrelated to the thorax were reviewed retrospectively in a case-control study. Computed tomography studies of 42 young dogs (range 0.3-4.8 years) and 47 old dogs (range 9-15.1 years) were jumbled and reviewed by an observer blinded to dog age. Computed tomography was performed under sedation in 62 (70%) dogs and under general anesthesia in 27 (30%). Heterotopic bone was more prevalent (62% vs. 14%) in old dogs. Lung collapse was significantly associated with old age, greater body weight, and anesthesia. There were no significant differences in median lung attenuation or occurrence of ground glass pattern, cysts, bronchial thickening, bronchial dilation, or degree of tracheal calcification. No examples of reticular pattern, emphysema, pleural thickening, or septal thickening were observed in any dog. Despite previous studies describing age-related changes in the radiographic appearance of the lungs of old dogs, it appears that there are minimal observable differences in CT images. Old dogs are more likely to have visible foci of heterotopic bone and may be more prone to lung lobe collapse than young dogs, but neither of these differences should contribute to misdiagnosis of pulmonary disease.
在人类的计算机断层扫描（CT）图像中，肺实质密度减低、支气管扩张和/或增厚、空气潴留、囊肿以及小叶间隔增厚与年龄增长有关。为了确定年轻和老年犬肺部CT表现是否存在差异，而这种差异可能会影响诊断研究的解读，在一项病例对照研究中，对患有与胸部无关疾病的犬的肺部CT图像进行了回顾性分析。将42只幼犬（年龄范围0.3 - 4.8岁）和47只老年犬（年龄范围9 - 15.1岁）的CT研究结果打乱，由一位对犬只年龄不知情的观察者进行审阅。62只（70%）犬在镇静状态下进行CT检查，27只（30%）在全身麻醉下进行检查。异位骨在老年犬中更为常见（62% 对14%）。肺萎陷与老年、体重增加和麻醉显著相关。肺实质密度中位数或磨玻璃影、囊肿、支气管增厚、支气管扩张或气管钙化程度的发生率没有显著差异。在任何一只犬中均未观察到网状影、肺气肿、胸膜增厚或间隔增厚的情况。尽管之前有研究描述了老年犬肺部X线表现的年龄相关变化，但似乎CT图像中可观察到的差异极小。老年犬比幼犬更有可能出现可见的异位骨灶，并且可能更容易发生肺叶萎陷，但这些差异均不应导致肺部疾病的误诊。
