Roels Elodie, Couvreur Thierry, Farnir Frédéric, Clercx Cécile, Verschakelen Johny, Bolen Géraldine
Department of Clinical Sciences, Fundamental and Applied Research for Animals & Health (FARAH), University of Liège, 4000, Liège, Belgium.
Department of Radiology, Christian Hospital Center Liège, Belgium.
Vet Radiol Ultrasound. 2017 May;58(3):284-294. doi: 10.1111/vru.12481. Epub 2017 Feb 23.
Canine idiopathic pulmonary fibrosis is a progressive interstitial lung disease mainly affecting West Highland white terriers. Thoracic high-resolution computed tomographic (T-HRCT) findings for Canine idiopathic pulmonary fibrosis acquired under general anesthesia have been described previously. However, the use of general anesthesia may be contraindicated for some affected dogs. Sedation may allow improved speed and safety, but it is unknown whether sedation would yield similar results in identification and grading of Canine idiopathic pulmonary fibrosis lesions. The aim of this prospective, observational, method-comparison, case-control study was to compare findings from T-HRCT images acquired under sedation versus general anesthesia for West Highland white terriers affected with Canine idiopathic pulmonary fibrosis (n = 11) and age-matched controls (n = 9), using the glossary of terms of the Fleischner Society and a scoring system. Ground-glass opacity was identified in all affected West Highland white terriers for both sedation and general anesthesia acquisitions, although the Ground-glass opacity extent varied significantly between the two acquisitions (P < 0.001). Ground-glass opacity was the sole lesion observed in control dogs (n = 6), but was less extensive compared with affected West Highland white terriers. Identification and grading of a mosaic attenuation pattern differed significantly between acquisitions (P < 0.001). Identification of lesions such as consolidations, nodules, parenchymal and subpleural bands, bronchial wall thickening, and bronchiectasis did not differ between acquisitions. The present study demonstrated that T-HRCT obtained under sedation may provide different information than T-HRCT obtained under general anesthesia for identification and grading of some Canine idiopathic pulmonary fibrosis lesions, but not all of them. These differences should be taken into consideration when general anesthesia is contraindicated and sedation is necessary for evaluating West Highland white terriers with Canine idiopathic pulmonary fibrosis.
犬特发性肺纤维化是一种主要影响西高地白梗的进行性间质性肺病。先前已描述了在全身麻醉下获得的犬特发性肺纤维化的胸部高分辨率计算机断层扫描（T-HRCT）结果。然而，全身麻醉的使用可能对一些患病犬是禁忌的。镇静可能会提高速度和安全性，但尚不清楚镇静在犬特发性肺纤维化病变的识别和分级中是否会产生类似的结果。这项前瞻性、观察性、方法比较、病例对照研究的目的是，使用 Fleischner 学会的术语表和评分系统，比较在镇静和全身麻醉下获得的 T-HRCT 图像对患有犬特发性肺纤维化的西高地白梗（n = 11）和年龄匹配的对照犬（n = 9）的检查结果。在镇静和全身麻醉采集的所有患病西高地白梗中均发现了磨玻璃影，尽管两次采集之间磨玻璃影的范围有显著差异（P < 0.001）。磨玻璃影是对照犬（n = 6）中观察到的唯一病变，但与患病西高地白梗相比范围较小。两次采集之间马赛克衰减模式的识别和分级有显著差异（P < 0.001）。实变、结节、实质和胸膜下带、支气管壁增厚和支气管扩张等病变的识别在两次采集之间没有差异。本研究表明，对于一些犬特发性肺纤维化病变的识别和分级，镇静下获得的 T-HRCT 可能提供与全身麻醉下获得的 T-HRCT 不同的信息，但并非所有病变都是如此。当全身麻醉禁忌且评估患有犬特发性肺纤维化的西高地白梗需要镇静时，应考虑这些差异。
