抗组胺化合物对不同成瘾性药物口服摄入量的影响。

The influence of antihistamine compounds on the oral intake of different addictive drugs.

作者信息

Fuchs V, Coper H

出版信息

Drug Alcohol Depend. 1986 Jul;17(4):359-64. doi: 10.1016/0376-8716(86)90085-2.

Abstract

The influence of two antihistamines on the oral intake of various drugs with addictive potency was investigated in rats. Under the chosen conditions neither tripelennamine nor diphenhydramine have reinforcing properties. The reinforcing potency of addictive drugs is not augmented by the both substances. On the contrary, in some cases they led to a decrease in oral intake of the drug solutions offered.

摘要

研究了两种抗组胺药对大鼠口服各种具有成瘾潜力药物的影响。在所选条件下，曲吡那敏和苯海拉明均无强化特性。这两种物质不会增强成瘾药物的强化效力。相反，在某些情况下，它们会导致所提供药物溶液的口服摄入量减少。