Johanson C E, Evans S, Henningfield J
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48207, USA.
Psychopharmacology (Berl). 1996 Jul;126(2):140-6. doi: 10.1007/BF02246349.
Twenty volunteers were trained to discriminate between 75 mg tripelennamine (TP) and placebo. During the first four sessions, the drugs were identified prior to ingestion by letter code. During the next six sessions, the procedure was the same except the capsules were not identified. At the end of the 3-h session, participants indicated which capsule they believed they received using the letter codes. When correct, they received a monetary bonus. If they were correct on five sessions, they entered the third phase which had ten additional training and 12 test sessions. During tests, participants received capsules that contained other drugs, including diphenhydramine (50 and 75 mg), chlorpheniramine (4 and 6 mg), diazepam (5 and 10 mg), d-amphetamine (5 and 10 mg), as well as tripelennamine (25, 50 and 75 mg) and placebo. Thirteen participants learned the discrimination and nine entered the third phase. Except for placebo, most participants identified the test compounds as TP and labeled them as sedatives. TP produced significant changes on several subjective and physiological measures. The test compounds produced varied effects which were neither clearly dose-related nor related to the identification as TP or placebo. These results indicate that tripelennamine can function as a discriminative stimulus, but with little evidence of pharmacological specificity.
20名志愿者接受了辨别75毫克曲吡那敏（TP）和安慰剂的训练。在前四个阶段，药物在摄入前通过字母代码进行识别。在接下来的六个阶段，程序相同，只是胶囊未作识别。在3小时的阶段结束时，参与者使用字母代码指出他们认为自己服用的是哪个胶囊。如果正确，他们会获得一笔金钱奖励。如果他们在五个阶段都正确，就进入第三阶段，该阶段还有十次额外的训练和12次测试阶段。在测试期间，参与者服用含有其他药物的胶囊，包括苯海拉明（50和75毫克）、氯苯那敏（4和6毫克）、地西泮（5和10毫克）、右旋苯丙胺（5和10毫克），以及曲吡那敏（25、50和75毫克）和安慰剂。13名参与者学会了辨别，9人进入第三阶段。除了安慰剂，大多数参与者将测试化合物识别为TP并将其标记为镇静剂。TP在几种主观和生理指标上产生了显著变化。测试化合物产生了不同的效果，这些效果既与剂量没有明显关联，也与被识别为TP或安慰剂无关。这些结果表明，曲吡那敏可以作为一种辨别性刺激物，但几乎没有药理学特异性的证据。
