Nagy-Grócz Gábor, Zádor Ferenc, Dvorácskó Szabolcs, Bohár Zsuzsanna, Benyhe Sándor, Tömböly Csaba, Párdutz Árpád, Vécsei László
MTA-SZTE Neuroscience Research Group, University of Szeged, H-6725 Szeged, Hungary.
Faculty of Health Sciences and Social Studies, University of Szeged, H-6726 Szeged, Hungary.
Int J Mol Sci. 2017 Jul 30;18(8):1617. doi: 10.3390/ijms18081617.
Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that there are interactions of two systems. Although their cooperation has not yet been implicated in migraine, there are reports suggesting this possibility. Additionally, the individual role of the endocannabinoid and kynurenine system in migraine is reviewed here first, focusing on endocannabinoids, kynurenine metabolites, in particular kynurenic acid. Finally, the function of NMDA and cannabinoid receptors in the trigeminal system-which has a crucial role in the pathomechanisms of migraine-will also be discussed. The interaction of the endocannabinoid and kynurenine system has been demonstrated to be therapeutically relevant in a number of pathological conditions, such as cannabis addiction, psychosis, schizophrenia and epilepsy. Accordingly, the cross-talk of these two systems may imply potential mechanisms related to migraine, and may offer new approaches to manage the treatment of this neurological disorder.
犬尿氨酸系统和内源性大麻素系统都与多种神经系统疾病有关，如偏头痛，并且越来越多的报告表明这两个系统之间存在相互作用。虽然它们的协同作用尚未被证实与偏头痛有关，但有报告提示了这种可能性。此外，本文首先综述了内源性大麻素系统和犬尿氨酸系统在偏头痛中的各自作用，重点关注内源性大麻素、犬尿氨酸代谢产物，尤其是犬尿酸。最后，还将讨论NMDA和大麻素受体在三叉神经系统中的功能，该系统在偏头痛的发病机制中起关键作用。内源性大麻素系统和犬尿氨酸系统的相互作用已被证明在许多病理状况下具有治疗相关性，如大麻成瘾、精神病、精神分裂症和癫痫。因此，这两个系统之间的相互作用可能意味着与偏头痛相关的潜在机制，并可能为这种神经系统疾病的治疗提供新的方法。
