运动衍生内源性大麻素组与犬尿氨酸之间的相互作用：肥胖和抑郁症状的潜在靶向疗法

Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms.

作者信息

Wences Chirino Tiffany, Rangel López Edgar, Luna Angulo Alexandra, Carrillo Mora Paul, Landa Solis Carlos, Samudio Cruz María Alejandra, Fuentes Bello Alim C, Paniagua Pérez Rogelio, Ríos Martínez Juan, Sánchez Chapul Laura

机构信息

Neuromuscular Diseases Laboratory, Clinical Neurosciences Division, National Institute of Rehabilitation "Luis Guillermo Ibarra Ibarra", Mexico City 14389, Mexico.

Cell Reprogramming Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.

出版信息

Pharmaceuticals (Basel). 2023 Oct 5;16(10):1421. doi: 10.3390/ph16101421.

DOI:10.3390/ph16101421

PMID:37895892

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10609722/

Abstract

The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of their respective metabolites-endocannabinoids (eCBs) and kynurenines (KYNs)-which overlap at some points, acting as important antidepressant, anti-nociceptive, anti-inflammatory, and antioxidant biomarkers. Therefore, the aim of this review is to analyze and discuss some recently performed studies to investigate the potential interactions between both systems, particularly those related to exercise-derived endocannabinoidome and kynurenine mechanisms, and to elucidate how prescription of physical exercise could represent a new approach for the clinical management of these two conditions.

摘要

已知犬尿氨酸途径（KP）和内源性大麻素系统（ECS）在抑郁症和肥胖症中失调；然而，人们已经认识到，急性体育锻炼具有重要的调节作用，可诱导其各自代谢产物——内源性大麻素（eCBs）和犬尿氨酸（KYNs）的动员发生变化，这两种代谢产物在某些方面存在重叠，可作为重要的抗抑郁、抗伤害感受、抗炎和抗氧化生物标志物。因此，本综述的目的是分析和讨论一些最近进行的研究，以探讨这两个系统之间的潜在相互作用，特别是那些与运动衍生的内源性大麻素组和犬尿氨酸机制相关的相互作用，并阐明体育锻炼的处方如何能够代表这两种病症临床管理的一种新方法。