缺血性心脏病患者唾液/血清中胃饥饿素、肥胖抑制素和同型半胱氨酸水平
Saliva/serum ghrelin, obestatin and homocysteine levels in patients with ischaemic heart disease.
作者信息
Kilic Nermin, Dagli Necati, Aydin Suleyman, Erman Fazilet, Bek Yuksel, Akin Okhan, Kilic S S, Erdemli Haci Kemal, Alacam Hasan
机构信息
Department of Medical Biochemistry, School of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Department of Cardiology, School of Medicine, Firat University, Elazig, Turkey.
出版信息
Cardiovasc J Afr. 2017 May/Jun;28(3):159-164. doi: 10.5830/CVJA-2016-075.
BACKGROUND
We aimed to compare ghrelin, obestatin, homocysteine (Hcy), vitamin B and folate levels in the serum and saliva of ischaemic heart disease patients.
METHODS
Serum and saliva were collected from 33 ischaemic heart disease (IHD) patients and 28 age- and body mass index-matched healthy individuals. Levels of acylated and desacylated ghrelin, obestatin and Hcy were determined using the ELISA method.
RESULTS
Acylated ghrelin, desacylated ghrelin and obestatin levels in the saliva were found to be higher than those in the serum of the control group, while acylated and desacylated ghrelin levels in the saliva were significantly lower than those in the serum. Obestatin levels were higher in IHD patients (p = 0.001). Saliva and serum vitamin B and folate levels in IHD patients were significantly lower than in the control group (p = 0.001).
CONCLUSIONS
It was determined that serum ghrelin levels increased in ischaemic heart disease patients, while serum levels of obestatin decreased.
背景
我们旨在比较缺血性心脏病患者血清和唾液中胃饥饿素、肥胖抑制素、同型半胱氨酸（Hcy）、维生素B和叶酸的水平。
方法
收集33例缺血性心脏病（IHD）患者以及28例年龄和体重指数匹配的健康个体的血清和唾液。采用酶联免疫吸附测定法（ELISA法）测定酰化和去酰化胃饥饿素、肥胖抑制素及Hcy的水平。
结果
发现唾液中酰化胃饥饿素、去酰化胃饥饿素和肥胖抑制素水平高于对照组血清中的水平，而唾液中酰化和去酰化胃饥饿素水平显著低于血清中的水平。IHD患者的肥胖抑制素水平较高（p = 0.001）。IHD患者唾液和血清中的维生素B和叶酸水平显著低于对照组（p = 0.001）。
结论
已确定缺血性心脏病患者血清胃饥饿素水平升高，而血清肥胖抑制素水平降低。
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