Department of Obstetrics and Gynecology, Firat University Hospital, Elazig, Turkey.
Clin Biochem. 2012 Feb;45(3):198-202. doi: 10.1016/j.clinbiochem.2011.08.1131. Epub 2011 Aug 25.
The present study aims to establish the levels of acylated ghrelin, desacylated ghrelin, obestatin and preptin, during pregnancy and the postpartum period in pregnant women with Gestational Diabetes Mellitus (GDM) and healthy pregnancy women.
The study registered 20 pregnant women with GDM and 20 healthy pregnant women. Fasting venous blood samples were collected from all cases between weeks 24 and 28 of pregnancy and after 24h postpartum. Hormones were analyzed using ELISA method.
Serum acylated ghrelin (p:0.001), desacylated ghrelin (p:0.001), obestatin (p:0.006) and preptin (p:0.001) levels were all found statistically higher in both groups during the postpartum period, when compared to the pregnancy period. A positive correlation was established between desacylated ghrelin and acylated ghrelin (p:0.008), desacylated ghrelin and preptin (p:0.012) and preptin and insulin (p:0.039) in the GDM group during pregnancy.
The studied hormones (especially desacylated ghrelin and obestatin) are critical in GDM pathophysiology based on the comparison of measure after and before the delivery.
本研究旨在建立妊娠糖尿病（GDM）孕妇和健康孕妇在妊娠和产后期间酰化 ghrelin、去酰化 ghrelin、obestatin 和 preptin 的水平。
本研究共纳入 20 名 GDM 孕妇和 20 名健康孕妇。所有病例均在妊娠 24-28 周和产后 24 小时内采集空腹静脉血样。采用 ELISA 法分析激素。
与妊娠期间相比，两组产后血清酰化 ghrelin（p：0.001）、去酰化 ghrelin（p：0.001）、obestatin（p：0.006）和 preptin（p：0.001）水平均明显升高。在 GDM 组妊娠期间，去酰化 ghrelin 与酰化 ghrelin 之间呈正相关（p：0.008），去酰化 ghrelin 与 preptin 之间呈正相关（p：0.012），preptin 与胰岛素之间呈正相关（p：0.039）。
根据分娩前后测量值的比较，研究中的激素（尤其是去酰化 ghrelin 和 obestatin）在 GDM 发病机制中具有重要作用。
