Sadeghi Atena, Bahramsoltani Roodabeh, Rahimi Roja, Farzaei Mohammad Hosein, Farzaei Fatemeh, Haghighi Zahra Minoosh Siavosh, Abdollahi Mohammad
a Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch , Islamic Azad University , Tehran , Iran.
b Department of Traditional Pharmacy, School of Traditional Medicine , Tehran University of Medical Sciences , Tehran , Iran.
J Diet Suppl. 2018 Mar 4;15(2):197-206. doi: 10.1080/19390211.2017.1343888. Epub 2017 Jul 31.
Nonalcoholic fatty liver disease (FLD) is a worldwide common liver disorder. Tragopogon graminifolius is used as a dietary supplement for liver disorders. This study aimed to assess the beneficial effects of a standardized preparation from T. graminifolius extract (TGE) in animal model of FLD induced by high-fat diet (HFD). The standardization of TGE based on phenolic compounds was performed using high-performance liquid chromatography (HPLC) analysis. The HFD induced metabolic and hepatic damages. TGE significantly reduced the elevations of serum triglyceride, cholesterol, low-density lipoprotein (LDL), and hepatic enzymes (p =.001 for 25, 50, and 100 mg/kg of TGE). Histopathological studies also confirmed beneficial effects of TGE in FLD. Activity of total antioxidant power, content of total thiol, myeloperoxidase (MPO) enzyme activity, and lipid peroxidation were significantly improved (p <.001). Dietary supplementation with TGE results in improvement of biochemical as well as histopathological parameters. Clinical trials are warranted to prove its efficacy and tolerability in patients with FLD.
非酒精性脂肪性肝病（FLD）是一种全球常见的肝脏疾病。禾本科婆罗门参被用作治疗肝脏疾病的膳食补充剂。本研究旨在评估禾本科婆罗门参提取物（TGE）的标准化制剂对高脂饮食（HFD）诱导的FLD动物模型的有益作用。基于酚类化合物对TGE进行标准化，采用高效液相色谱（HPLC）分析。HFD导致代谢和肝脏损伤。TGE显著降低了血清甘油三酯、胆固醇、低密度脂蛋白（LDL）和肝酶的升高（25、50和100mg/kg的TGE，p = 0.001）。组织病理学研究也证实了TGE对FLD的有益作用。总抗氧化能力、总硫醇含量、髓过氧化物酶（MPO）酶活性和脂质过氧化均显著改善（p < 0.001）。补充TGE饮食可改善生化和组织病理学参数。有必要进行临床试验以证明其对FLD患者的疗效和耐受性。
