Davoodi Ida, Rahimi Roja, Abdollahi Mohammad, Farzaei Fatemeh, Farzaei Mohammad Hosein, Memariani Zahra, Najafi Fariba
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Tradit Complement Med. 2017 Feb 13;7(4):508-514. doi: 10.1016/j.jtcme.2017.01.008. eCollection 2017 Oct.
NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages. Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract of on animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase ( < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels. significantly reduced the elevation of final body weight, liver fat accumulation, TG, TC, LDL-C concentrations and hepatic enzymes ( < 0.05). Histopathological examination of hepatic tissue confirmed the therapeutic effect of Improvement of total antioxidant power activity, total thiol content, MPO enzyme activity, and also lipid peroxidation were also considered in treated animals ( < 0.05). HPLC analysis showed that phenolic compounds including gallic acid, quercetin and syringic acid are the main bioactive compounds of hydroalcoholic extract. In conclusion, dietary supplementation has a therapeutic effect in NAFLD. Improvement of oxidative stress associated damage in liver tissue is among the main pharmacological mechanisms involved in therapeutic activity of the plant.
非酒精性脂肪性肝病（NAFLD）是一种慢性肝病，影响着世界上很大一部分人口，会导致代谢和肝脏损伤。水飞蓟传统上用作肝脏疾病的膳食补充剂。本研究旨在确定水飞蓟标准化提取物对非酒精性脂肪性肝病（NAFLD）动物模型的有益作用。通过高脂饮食（HFD）诱导Wistar大鼠患NAFLD。HFD大鼠的血浆总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）水平升高（P<0.05），高密度脂蛋白（HDL）水平降低。水飞蓟显著降低了最终体重的增加、肝脏脂肪堆积、TG、TC、低密度脂蛋白胆固醇（LDL-C）浓度以及肝酶水平（P<0.05）。肝组织的组织病理学检查证实了水飞蓟的治疗效果。在治疗的动物中还观察到总抗氧化能力活性、总硫醇含量、髓过氧化物酶（MPO）酶活性以及脂质过氧化的改善（P<0.05）。高效液相色谱（HPLC）分析表明，没食子酸、槲皮素和丁香酸等酚类化合物是水飞蓟水醇提取物的主要生物活性成分。总之，水飞蓟膳食补充剂对NAFLD有治疗作用。改善肝组织中与氧化应激相关的损伤是该植物治疗活性所涉及的主要药理机制之一。
