抗精子抗体的检测：细胞毒性固定试验。

Detection of antisperm antibodies: a cytotoxicity immobilization test.

作者信息

Blumenfeld Z, Gershon H, Makler A, Stoler J, Brandes J M

出版信息

Int J Fertil. 1986 Jul-Aug;31(3):207-12.

Abstract

The sera of 110 couples with unexplained infertility were examined for anti-sperm immobilizing antibodies with the aid of multiple-exposure photography. The sera of 10 females and 3 males had immobilizing activity. Eleven pregnancies occurred in 10 female patients in the group without immobilizing antibodies. None of the 13 females in the couples with immobilizing activity conceived. A negative correlation was found between the occurrence of serum immobilizing antibodies and incidence of pregnancy. No such correlation could be found between the occurrence of autoagglutination in the male's ejaculate and the female partner conceiving. In light of detection of anti-sperm antibodies in a patient with habitual abortions, a possible immune mechanism is suggested.

摘要

借助多次曝光摄影技术，对110对不明原因不孕夫妇的血清进行了抗精子制动抗体检测。10名女性和3名男性的血清具有制动活性。在无制动抗体组的10名女性患者中发生了11次妊娠。具有制动活性的夫妇中，13名女性无一受孕。发现血清制动抗体的出现与妊娠发生率呈负相关。在男性精液中自身凝集的出现与女性伴侣受孕之间未发现此类相关性。鉴于在习惯性流产患者中检测到抗精子抗体，提出了一种可能的免疫机制。