Donat H
Zentralbl Gynakol. 1985;107(23):1401-8.
A review is given about the actual knowledge of sperm antigens and antibodies. For the detection of sperm antibodies a great number of tests exists with different value for the clinical work. The penetration tests are suitable for screening investigations. It has been established that in the last time the direct mixed antiglobulin reaction (MAR test), the immunobead binding technique, and the panning procedure were involved in the searching of antibodies bounded on the sperm cells. For the evaluation of circulating sperm antibodies in serum, cervical mucus, and seminal plasma the agglutination tests, the immobilization test, and the indirect MAR test are recommendable. The determination of immunoglobulin class of sperm antibodies is important because the IgA globulins are more effective than IgG in these cases.
本文综述了精子抗原和抗体的现有知识。对于精子抗体的检测,有大量的检测方法,它们在临床工作中的价值各不相同。穿透试验适用于筛查研究。已经确定,最近直接混合抗球蛋白反应(MAR试验)、免疫珠结合技术和平板淘选法被用于寻找结合在精子细胞上的抗体。对于评估血清、宫颈黏液和精浆中循环精子抗体,推荐使用凝集试验、制动试验和间接MAR试验。确定精子抗体的免疫球蛋白类别很重要,因为在这些情况下,IgA球蛋白比IgG更有效。